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. 2002 Dec;3(6):499–503. doi: 10.1002/cfg.220

Learning About Gene Regulatory Networks From Gene Deletion Experiments

Thomas Schlitt 1,✉, Alvis Brazma 1
PMCID: PMC2448417  PMID: 18629255

Abstract

Gene regulatory networks are a major focus of interest in molecular biology. A crucial question is how complex regulatory systems are encoded and controlled by the genome. Three recent publications have raised the question of what can be learned about gene regulatory networks from microarray experiments on gene deletion mutants. Using this indirect approach, topological features such as connectivity and modularity have been studied.

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Selected References

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