Skip to main content
NCBI home page
The Ulster Medical Journal logoLink to The Ulster Medical Journal
. 1988 Apr;57(1):50–57.

The effect of exposure to mupirocin on the survival and recovery of sensitive Staphylococcus aureus strains

J G Barr, G M Hogg, E T M Smyth
PMCID: PMC2448482  PMID: 3138804

Abstract

A significant percentage survival, representing a large number of viable cells, can occur in a Staphylococcus aureus population exposed to concentrations of mupirocin up to 1,000 times the minimum inhibitory concentration. An elevated ratio of minimum inhibitory to minimum bactericidal concentration of mupirocin with staphylococci was recorded. Staphylococci which survive exposure to mupirocin may be less sensitive to the subsequent bactericidal action of the antibiotic. The observations may explain the re-colonisation with staphylococci seen in some studies.

Full text

PDF
50

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker L. F. Pests in hospitals. J Hosp Infect. 1981 Mar;2(1):5–9. doi: 10.1016/0195-6701(81)90002-5. [DOI] [PubMed] [Google Scholar]
  2. Baynes N. C., Comrie J., Prain J. H. Detection of bacterial growth by the Malthus conductance meter. Med Lab Sci. 1983 Apr;40(2):149–158. [PubMed] [Google Scholar]
  3. Brumfitt W., Dixson S., Hamilton-Miller J. M. Resistance to antiseptics in methicillin and gentamicin resistant Staphylococcus aureus. Lancet. 1985 Jun 22;1(8443):1442–1443. doi: 10.1016/s0140-6736(85)91863-x. [DOI] [PubMed] [Google Scholar]
  4. Dacre J., Emmerson A. M., Jenner E. A. Gentamicin-methicillin-resistant Staphylococcus aureus: epidemiology and containment of an outbreak. J Hosp Infect. 1986 Mar;7(2):130–136. doi: 10.1016/0195-6701(86)90055-1. [DOI] [PubMed] [Google Scholar]
  5. Locksley R. M., Cohen M. L., Quinn T. C., Tompkins L. S., Coyle M. B., Kirihara J. M., Counts G. W. Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection. Ann Intern Med. 1982 Sep;97(3):317–324. doi: 10.7326/0003-4819-97-3-317. [DOI] [PubMed] [Google Scholar]
  6. Price E. H., Brain A., Dickson J. A. An outbreak of infection with a gentamicin and methicillin-resistant Staphylococcus aureus in a neonatal unit. J Hosp Infect. 1980 Sep;1(3):221–228. doi: 10.1016/0195-6701(80)90059-6. [DOI] [PubMed] [Google Scholar]
  7. Rimland D., Roberson B. Gastrointestinal carriage of methicillin-resistant Staphylococcus aureus. J Clin Microbiol. 1986 Jul;24(1):137–138. doi: 10.1128/jcm.24.1.137-138.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Shanson D. C. Antibiotic-resistant Staphylococcus aureus. J Hosp Infect. 1981 Mar;2(1):11–36. doi: 10.1016/0195-6701(81)90003-7. [DOI] [PubMed] [Google Scholar]
  9. Shanson D. C., McSwiggan D. A. Operating theatre acquired infection with a gentamicin-resistant strain of Staphylococcus aureus: outbreaks in two hospitals attributable to one surgeon. J Hosp Infect. 1980 Jun;1(2):171–172. doi: 10.1016/0195-6701(80)90050-x. [DOI] [PubMed] [Google Scholar]
  10. Wyatt T. D., Ferguson W. P., Wilson T. S., McCormick E. Gentamicin resistant Staphylococcus aureus associated with the use of topical gentamicin. J Antimicrob Chemother. 1977 May;3(3):213–217. doi: 10.1093/jac/3.3.213. [DOI] [PubMed] [Google Scholar]

Articles from The Ulster Medical Journal are provided here courtesy of Ulster Medical Society

RESOURCES