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. 1991 Oct;60(2):159–163.

Hepatitis delta virus infection in Northern Ireland 1970-1989.

R A Curran 1, H J O'Neill 1, J H Connolly 1
PMCID: PMC2448660  PMID: 1785149

Abstract

The incidence of hepatitis delta virus (HDV) infection in Northern Ireland (1970-1989) was tested by enzyme linked immunosorbent assay in 401 hepatitis B surface antigen (HBsAg) positive sera. Hepatitis delta antigen (HDAg) was tested in 388 patients and antibody to delta antigen (anti-HD) in 401 patients. Four patients (1.03%) were HDAg positive. Nine patients (2.24%) were positive for anti-HD and after acid pre-treatment of sera from eight of these patients, five were positive for HDAg. The overall incidence of HDV markers was 3.27%, which reflects the low incidence in HBsAg carriers in Northern Ireland (who were in high risk groups for delta hepatitis). The use of acid treatment of the sera to break up antigen/antibody complexes has been a useful technological improvement in the identification of this virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bezeaud A., Rosenswajg M., Guillin M. C. Evaluation of five hepatitis delta virus marker assays for detection of antigen and antibody. J Clin Microbiol. 1989 Dec;27(12):2880–2880. doi: 10.1128/jcm.27.12.2880-.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Connolly J. H., McClelland W. M., O'Neill H. J., Crowley D. Hepatitis B virus infection in Northern Ireland 1970-1987. Ulster Med J. 1989 Apr;58(1):72–82. [PMC free article] [PubMed] [Google Scholar]
  3. Fagan E., Vergani D., Williams R. Delta hepatitis. Lancet. 1987 Dec 5;2(8571):1322–1323. doi: 10.1016/s0140-6736(87)91206-2. [DOI] [PubMed] [Google Scholar]
  4. Hadler S. C., De Monzon M., Ponzetto A., Anzola E., Rivero D., Mondolfi A., Bracho A., Francis D. P., Gerber M. A., Thung S. Delta virus infection and severe hepatitis. An epidemic in the Yucpa Indians of Venezuela. Ann Intern Med. 1984 Mar;100(3):339–344. doi: 10.7326/0003-4819-100-3-339. [DOI] [PubMed] [Google Scholar]
  5. Hoofnagle J. H. Type D (delta) hepatitis. JAMA. 1989 Mar 3;261(9):1321–1325. [PubMed] [Google Scholar]
  6. Kelly V., Kensit J., Barrett A. Hepatitis D (delta) infection in south-east London. Lancet. 1989 Jan 7;1(8628):45–45. doi: 10.1016/s0140-6736(89)91701-7. [DOI] [PubMed] [Google Scholar]
  7. Ljunggren K. E., Patarroyo M. E., Engle R., Purcell R. H., Gerin J. L. Viral hepatitis in Colombia: a study of the "hepatitis of the Sierra Nevada de Santa Marta". Hepatology. 1985 Mar-Apr;5(2):299–304. doi: 10.1002/hep.1840050225. [DOI] [PubMed] [Google Scholar]
  8. McCruden E. A., Follett E. A. Hepatitis delta virus infections in intravenous drug abusers with hepatitis B in the west of Scotland. J Med Virol. 1989 Sep;29(1):59–62. doi: 10.1002/jmv.1890290111. [DOI] [PubMed] [Google Scholar]
  9. Nishanian P., Huskins K. R., Stehn S., Detels R., Fahey J. L. A simple method for improved assay demonstrates that HIV p24 antigen is present as immune complexes in most sera from HIV-infected individuals. J Infect Dis. 1990 Jul;162(1):21–28. doi: 10.1093/infdis/162.1.21. [DOI] [PubMed] [Google Scholar]
  10. Polakoff S. Decrease in acute hepatitis B incidence continued in 1987. Lancet. 1988 Mar 5;1(8584):540–540. doi: 10.1016/s0140-6736(88)91343-8. [DOI] [PubMed] [Google Scholar]
  11. Rosina F., Saracco G., Rizzetto M. Risk of post-transfusion infection with the hepatitis delta virus. A multicenter study. N Engl J Med. 1985 Jun 6;312(23):1488–1491. doi: 10.1056/NEJM198506063122305. [DOI] [PubMed] [Google Scholar]
  12. Shattock A. G., Kelly M. G., Fielding J., Arthurs Y. Epidemic hepatitis B with delta-antigenaemia among Dublin drug-abusers. Ir J Med Sci. 1982 Nov;151(11):334–338. doi: 10.1007/BF02940218. [DOI] [PubMed] [Google Scholar]
  13. Shattock A. G., Morris M., Kinane K., Fagan C. The serology of delta hepatitis and the detection of IgM anti-HD by EIA using serum derived delta antigen. J Virol Methods. 1989 Mar;23(3):233–240. doi: 10.1016/0166-0934(89)90156-0. [DOI] [PubMed] [Google Scholar]
  14. Turner G. C., Panton N., Vandervelde E. M. Delta infection and drug abuse in Merseyside. J Infect. 1989 Sep;19(2):113–118. doi: 10.1016/s0163-4453(89)91814-8. [DOI] [PubMed] [Google Scholar]

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