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. 1994 Oct;63(2):193–200.

The L-arginine/nitric oxide pathway--biological properties and therapeutic applications.

P J Neilly 1, S J Kirk 1, K R Gardiner 1, B J Rowlands 1
PMCID: PMC2448752  PMID: 8650833

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams L. B., Franzblau S. G., Vavrin Z., Hibbs J. B., Jr, Krahenbuhl J. L. L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae. J Immunol. 1991 Sep 1;147(5):1642–1646. [PubMed] [Google Scholar]
  2. Albina J. E., Caldwell M. D., Henry W. L., Jr, Mills C. D. Regulation of macrophage functions by L-arginine. J Exp Med. 1989 Mar 1;169(3):1021–1029. doi: 10.1084/jem.169.3.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Alexander J. W., MacMillan B. G., Stinnett J. D., Ogle C. K., Bozian R. C., Fischer J. E., Oakes J. B., Morris M. J., Krummel R. Beneficial effects of aggressive protein feeding in severely burned children. Ann Surg. 1980;192(4):505–517. doi: 10.1097/00000658-198010000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barbul A. Arginine and immune function. Nutrition. 1990 Jan-Feb;6(1):53–62. [PubMed] [Google Scholar]
  5. Barbul A. Arginine: biochemistry, physiology, and therapeutic implications. JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):227–238. doi: 10.1177/0148607186010002227. [DOI] [PubMed] [Google Scholar]
  6. Barbul A., Fishel R. S., Shimazu S., Wasserkrug H. L., Yoshimura N. N., Tao R. C., Efron G. Intravenous hyperalimentation with high arginine levels improves wound healing and immune function. J Surg Res. 1985 Apr;38(4):328–334. doi: 10.1016/0022-4804(85)90045-9. [DOI] [PubMed] [Google Scholar]
  7. Barbul A., Lazarou S. A., Efron D. T., Wasserkrug H. L., Efron G. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990 Aug;108(2):331–337. [PubMed] [Google Scholar]
  8. Barbul A., Rettura G., Levenson S. M., Seifter E. Arginine: a thymotropic and wound-healing promoting agent. Surg Forum. 1977;28:101–103. [PubMed] [Google Scholar]
  9. Barbul A., Sisto D. A., Wasserkrug H. L., Efron G. Arginine stimulates lymphocyte immune response in healthy human beings. Surgery. 1981 Aug;90(2):244–251. [PubMed] [Google Scholar]
  10. Barbul A., Wasserkrug H. L., Seifter E., Rettura G., Levenson S. M., Efron G. Immunostimulatory effects of arginine in normal and injured rats. J Surg Res. 1980 Sep;29(3):228–235. doi: 10.1016/0022-4804(80)90165-1. [DOI] [PubMed] [Google Scholar]
  11. Barbul A., Wasserkrug H. L., Yoshimura N., Tao R., Efron G. High arginine levels in intravenous hyperalimentation abrogate post-traumatic immune suppression. J Surg Res. 1984 Jun;36(6):620–624. doi: 10.1016/0022-4804(84)90149-5. [DOI] [PubMed] [Google Scholar]
  12. Boughton-Smith N. K., Evans S. M., Hawkey C. J., Cole A. T., Balsitis M., Whittle B. J., Moncada S. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet. 1993 Aug 7;342(8867):338–340. doi: 10.1016/0140-6736(93)91476-3. [DOI] [PubMed] [Google Scholar]
  13. Bower R. H., Muggia-Sullam M., Vallgren S., Hurst J. M., Kern K. A., LaFrance R., Fischer J. E. Branched chain amino acid-enriched solutions in the septic patient. A randomized, prospective trial. Ann Surg. 1986 Jan;203(1):13–20. doi: 10.1097/00000658-198601000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Burke D. J., Alverdy J. C., Aoys E., Moss G. S. Glutamine-supplemented total parenteral nutrition improves gut immune function. Arch Surg. 1989 Dec;124(12):1396–1399. doi: 10.1001/archsurg.1989.01410120042009. [DOI] [PubMed] [Google Scholar]
  15. Cerra F. B., Lehmann S., Konstantinides N., Dzik J., Fish J., Konstantinides F., LiCari J. J., Holman R. T. Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA, and menhaden oil is independent of nitrogen balance. Nutrition. 1991 May-Jun;7(3):193–199. [PubMed] [Google Scholar]
  16. Cho-Chung Y. S., Clair T., Bodwin J. S., Hill D. M. Arrest of mammary tumor growth in vivo by L-arginine: stimulation of NAD-dependent activation of adenylate cyclase. Biochem Biophys Res Commun. 1980 Aug 14;95(3):1306–1313. doi: 10.1016/0006-291x(80)91616-2. [DOI] [PubMed] [Google Scholar]
  17. Daly J. M., Lieberman M. D., Goldfine J., Shou J., Weintraub F., Rosato E. F., Lavin P. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery. 1992 Jul;112(1):56–67. [PubMed] [Google Scholar]
  18. Daly J. M., Reynolds H. M., Jr, Copeland E. M., 3rd, Dudrick S. J. Effects of enteral and parenteral nutrition on tumor response to chemotherapy in experimental animals. J Surg Oncol. 1981;16(1):79–86. doi: 10.1002/jso.2930160112. [DOI] [PubMed] [Google Scholar]
  19. Daly J. M., Reynolds J., Thom A., Kinsley L., Dietrick-Gallagher M., Shou J., Ruggieri B. Immune and metabolic effects of arginine in the surgical patient. Ann Surg. 1988 Oct;208(4):512–523. doi: 10.1097/00000658-198810000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. EAGLE H. Amino acid metabolism in mammalian cell cultures. Science. 1959 Aug 21;130(3373):432–437. doi: 10.1126/science.130.3373.432. [DOI] [PubMed] [Google Scholar]
  21. FAHEY J. L. Toxicity and blood ammonia rise resulting from intravenous amino acid administration in man: the protective effect of l-arginine. J Clin Invest. 1957 Dec;36(12):1647–1655. doi: 10.1172/JCI103565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Floyd J. C., Jr, Fajans S. S., Conn J. W., Knopf R. F., Rull J. Stimulation of insulin secretion by amino acids. J Clin Invest. 1966 Sep;45(9):1487–1502. doi: 10.1172/JCI105456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Freund H., Atamian S., Holroyde J., Fischer J. E. Plasma amino acids as predictors of the severity and outcome of sepsis. Ann Surg. 1979 Nov;190(5):571–576. doi: 10.1097/00000658-197911000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Gonce S. J., Peck M. D., Alexander J. W., Miskell P. W. Arginine supplementation and its effect on established peritonitis in guinea pigs. JPEN J Parenter Enteral Nutr. 1990 May-Jun;14(3):237–244. doi: 10.1177/0148607190014003237. [DOI] [PubMed] [Google Scholar]
  25. Granger D. L., Taintor R. R., Cook J. L., Hibbs J. B., Jr Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration. J Clin Invest. 1980 Feb;65(2):357–370. doi: 10.1172/JCI109679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Hibbs J. B., Jr, Taintor R. R., Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science. 1987 Jan 23;235(4787):473–476. doi: 10.1126/science.2432665. [DOI] [PubMed] [Google Scholar]
  27. Keller R., Keist R., Klauser S., Schweiger A. The macrophage response to bacteria: flow of L-arginine through the nitric oxide and urea pathways and induction of tumoricidal activity. Biochem Biophys Res Commun. 1991 Jun 14;177(2):821–827. doi: 10.1016/0006-291x(91)91863-8. [DOI] [PubMed] [Google Scholar]
  28. Kirk S. J., Regan M. C., Barbul A. Cloned murine T lymphocytes synthesize a molecule with the biological characteristics of nitric oxide. Biochem Biophys Res Commun. 1990 Dec 14;173(2):660–665. doi: 10.1016/s0006-291x(05)80086-5. [DOI] [PubMed] [Google Scholar]
  29. Madden H. P., Breslin R. J., Wasserkrug H. L., Efron G., Barbul A. Stimulation of T cell immunity by arginine enhances survival in peritonitis. J Surg Res. 1988 Jun;44(6):658–663. doi: 10.1016/0022-4804(88)90097-2. [DOI] [PubMed] [Google Scholar]
  30. Merimee T. J., Lillicrap D. A., Rabinowitz D. Effect of arginine on serum-levels of human growth-hormone. Lancet. 1965 Oct 2;2(7414):668–670. doi: 10.1016/s0140-6736(65)90399-5. [DOI] [PubMed] [Google Scholar]
  31. Miller M. J., Sadowska-Krowicka H., Chotinaruemol S., Kakkis J. L., Clark D. A. Amelioration of chronic ileitis by nitric oxide synthase inhibition. J Pharmacol Exp Ther. 1993 Jan;264(1):11–16. [PubMed] [Google Scholar]
  32. Moncada S., Palmer R. M., Higgs E. A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991 Jun;43(2):109–142. [PubMed] [Google Scholar]
  33. Moore F. A., Moore E. E., Jones T. N., McCroskey B. L., Peterson V. M. TEN versus TPN following major abdominal trauma--reduced septic morbidity. J Trauma. 1989 Jul;29(7):916–923. doi: 10.1097/00005373-198907000-00003. [DOI] [PubMed] [Google Scholar]
  34. Morris G. P., Beck P. L., Herridge M. S., Depew W. T., Szewczuk M. R., Wallace J. L. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology. 1989 Mar;96(3):795–803. [PubMed] [Google Scholar]
  35. Mullen J. L., Buzby G. P., Matthews D. C., Smale B. F., Rosato E. F. Reduction of operative morbidity and mortality by combined preoperative and postoperative nutritional support. Ann Surg. 1980 Nov;192(5):604–613. doi: 10.1097/00000658-198019250-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. NAKAGAWA I., TAKAHASHI T., SUZUKI T., KOBAYASHI K. Amino acid requirements of children: minimal needs of tryptophan, arginine and histidine based on nitrogen balance method. J Nutr. 1963 Jul;80:305–310. doi: 10.1093/jn/80.3.305. [DOI] [PubMed] [Google Scholar]
  37. Park K. G., Hayes P. D., Garlick P. J., Sewell H., Eremin O. Stimulation of lymphocyte natural cytotoxicity by L-arginine. Lancet. 1991 Mar 16;337(8742):645–646. doi: 10.1016/0140-6736(91)92456-c. [DOI] [PubMed] [Google Scholar]
  38. Park K. G., Heys S. D., Blessing K., Kelly P., McNurlan M. A., Eremin O., Garlick P. J. Stimulation of human breast cancers by dietary L-arginine. Clin Sci (Lond) 1992 Apr;82(4):413–417. doi: 10.1042/cs0820413. [DOI] [PubMed] [Google Scholar]
  39. ROSE W. C., HAINES W. J., WARNER D. T. The amino acid requirements of man. V. The rôle of lysine, arginine, and tryptophan. J Biol Chem. 1954 Jan;206(1):421–430. [PubMed] [Google Scholar]
  40. Radomski M. W., Palmer R. M., Moncada S. Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol. 1987 Sep;92(1):181–187. doi: 10.1111/j.1476-5381.1987.tb11310.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Ratner S. Enzymes of arginine and urea synthesis. Adv Enzymol Relat Areas Mol Biol. 1973;39:1–90. doi: 10.1002/9780470122846.ch1. [DOI] [PubMed] [Google Scholar]
  42. Reynolds H. M., Jr, Daly J. M., Rowlands B. J., Dudrick S. J., Copeland E. M., 3rd Effects of nutritional repletion on host and tumor response to chemotherapy. Cancer. 1980 Jun 15;45(12):3069–3074. doi: 10.1002/1097-0142(19800615)45:12<3069::aid-cncr2820451232>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  43. Reynolds J. V., Daly J. M., Zhang S., Evantash E., Shou J., Sigal R., Ziegler M. M. Immunomodulatory mechanisms of arginine. Surgery. 1988 Aug;104(2):142–151. [PubMed] [Google Scholar]
  44. Reynolds J. V., Thom A. K., Zhang S. M., Ziegler M. M., Naji A., Daly J. M. Arginine, protein malnutrition, and cancer. J Surg Res. 1988 Dec;45(6):513–522. doi: 10.1016/0022-4804(88)90138-2. [DOI] [PubMed] [Google Scholar]
  45. Rogers Q. R., Freedland R. A., Symmons R. A. In vivo synthesis and utilization of arginine in the rat. Am J Physiol. 1972 Jul;223(1):236–240. doi: 10.1152/ajplegacy.1972.223.1.236. [DOI] [PubMed] [Google Scholar]
  46. Saito H., Trocki O., Wang S. L., Gonce S. J., Joffe S. N., Alexander J. W. Metabolic and immune effects of dietary arginine supplementation after burn. Arch Surg. 1987 Jul;122(7):784–789. doi: 10.1001/archsurg.1987.01400190050010. [DOI] [PubMed] [Google Scholar]
  47. Siegel J. H., Cerra F. B., Coleman B., Giovannini I., Shetye M., Border J. R., McMenamy R. H. Physiological and metabolic correlations in human sepsis. Invited commentary. Surgery. 1979 Aug;86(2):163–193. [PubMed] [Google Scholar]
  48. Sitren H. S., Fisher H. Nitrogen retention in rats fed on diets enriched with arginine and glycine. 1. Improved N retention after trauma. Br J Nutr. 1977 Mar;37(2):195–208. doi: 10.1079/bjn19770021. [DOI] [PubMed] [Google Scholar]
  49. Sodeyama M., Kirk S. J., Regan M. C., Barbul A. The effect of hemorrhagic shock on intestinal amino acid absorption in vivo. Circ Shock. 1992 Nov;38(3):153–156. [PubMed] [Google Scholar]
  50. Tachibana K., Mukai K., Hiraoka I., Moriguchi S., Takama S., Kishino Y. Evaluation of the effect of arginine-enriched amino acid solution on tumor growth. JPEN J Parenter Enteral Nutr. 1985 Jul-Aug;9(4):428–434. doi: 10.1177/0148607185009004428. [DOI] [PubMed] [Google Scholar]
  51. Takeda Y., Tominaga T., Tei N., Kitamura M., Taga S. Inhibitory effect of L-arginine on growth of rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene. Cancer Res. 1975 Sep;35(9):2390–2393. [PubMed] [Google Scholar]
  52. Weir G. C., Samols E., Loo S., Patel Y. C., Gabbay K. H. Somatostatin and pancreatic polypeptide secretion: effects of glucagon, insulin, and arginine. Diabetes. 1979 Jan;28(1):35–40. [PubMed] [Google Scholar]
  53. Weisburger J. H., Yamamoto R. S., Glass R. M., Frankel H. H. Prevention by arginine glutamate of the carcinogenicity of acetamide in rats. Toxicol Appl Pharmacol. 1969 Jan;14(1):163–175. doi: 10.1016/0041-008x(69)90176-8. [DOI] [PubMed] [Google Scholar]
  54. Wright C. D., Mülsch A., Busse R., Osswald H. Generation of nitric oxide by human neutrophils. Biochem Biophys Res Commun. 1989 Apr 28;160(2):813–819. doi: 10.1016/0006-291x(89)92506-0. [DOI] [PubMed] [Google Scholar]

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