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. 1998 Nov;67(2):104–109.

A cluster of suspected Pneumocystis carinii Pneumonia following intensive chemotherapy in a Belfast haematology unit.

Y L Ong 1, F G Jones 1
PMCID: PMC2448980  PMID: 9885546

Abstract

Five cases of pneumocystis carinii pneumonia were diagnosed in adult patients following intensive chemotherapy in the Royal Group of Hospitals haematology unit, Belfast, within a space of six months. The common features and the risk factors contributing to the increased susceptibility of these patients are discussed, as are the likely mechanisms of transmission of infection.

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Selected References

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  1. Atzori C., Lu J. J., Jiang B., Bartlett M. S., Orlando G., Queener S. F., Smith J. W., Cargnel A., Lee C. H. Diagnosis of Pneumocystis carinii pneumonia in AIDS patients by using polymerase chain reactions on serum specimens. J Infect Dis. 1995 Dec;172(6):1623–1626. doi: 10.1093/infdis/172.6.1623. [DOI] [PubMed] [Google Scholar]
  2. Bennett C. L., Horner R. D., Weinstein R. A., Kessler H. A., Dickinson G. M., Pitrak D. L., Gilman S. C., George W. L., Cohn S. E., Simberkoff M. S. Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami: 1987-1990. J Infect Dis. 1995 Jul;172(1):312–315. doi: 10.1093/infdis/172.1.312. [DOI] [PubMed] [Google Scholar]
  3. Castagnola E., Dini G., Lanino E., Tasso L., Dallorso S., Garaventa A., Rossi G. A., Giacchino R. Low CD4 lymphocyte count in a patient with P. carinii pneumonia after autologous bone marrow transplantation. Bone Marrow Transplant. 1995 Jun;15(6):977–978. [PubMed] [Google Scholar]
  4. Chen W., Gigliotti F., Harmsen A. G. Latency is not an inevitable outcome of infection with Pneumocystis carinii. Infect Immun. 1993 Dec;61(12):5406–5409. doi: 10.1128/iai.61.12.5406-5409.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hughes W. T., Kuhn S., Chaudhary S., Feldman S., Verzosa M., Aur R. J., Pratt C., George S. L. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1977 Dec 29;297(26):1419–1426. doi: 10.1056/NEJM197712292972602. [DOI] [PubMed] [Google Scholar]
  6. Keely S. P., Stringer J. R., Baughman R. P., Linke M. J., Walzer P. D., Smulian A. G. Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. J Infect Dis. 1995 Aug;172(2):595–598. doi: 10.1093/infdis/172.2.595. [DOI] [PubMed] [Google Scholar]
  7. Larson R. A., Dodge R. K., Burns C. P., Lee E. J., Stone R. M., Schulman P., Duggan D., Davey F. R., Sobol R. E., Frankel S. R. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811. Blood. 1995 Apr 15;85(8):2025–2037. [PubMed] [Google Scholar]
  8. Lyytikäinen O., Elonen E., Lautenschlager I., Jokipii A., Tiittanen L., Ruutu P. Pneumocystis carinii pneumonia in adults with acute leukaemia: is there a need for primary chemoprophylaxis? Eur J Haematol. 1996 Mar;56(3):188–189. doi: 10.1111/j.1600-0609.1996.tb01343.x. [DOI] [PubMed] [Google Scholar]
  9. Miller R. F., Millar A. B., Weller I. V., Semple S. J. Empirical treatment without bronchoscopy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Thorax. 1989 Jul;44(7):559–564. doi: 10.1136/thx.44.7.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Peglow S. L., Smulian A. G., Linke M. J., Pogue C. L., Nurre S., Crisler J., Phair J., Gold J. W., Armstrong D., Walzer P. D. Serologic responses to Pneumocystis carinii antigens in health and disease. J Infect Dis. 1990 Feb;161(2):296–306. doi: 10.1093/infdis/161.2.296. [DOI] [PubMed] [Google Scholar]
  11. Richards C. G., Wakefield A. E., Mitchell C. D. Detection of pneumocystis DNA in nasopharyngeal aspirates of leukaemic infants with pneumonia. Arch Dis Child. 1994 Sep;71(3):254–255. doi: 10.1136/adc.71.3.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Siminski J., Kidd P., Phillips G. D., Collins C., Raghu G. Reversed helper/suppressor T-lymphocyte ratio in bronchoalveolar lavage fluid from patients with breast cancer and Pneumocystis carinii pneumonia. Am Rev Respir Dis. 1991 Feb;143(2):437–440. doi: 10.1164/ajrccm/143.2.437. [DOI] [PubMed] [Google Scholar]
  13. Stringer J. R. The identity of Pneumocystis carinii: not a single protozoan, but a diverse group of exotic fungi. Infect Agents Dis. 1993 Jun;2(3):109–117. [PubMed] [Google Scholar]
  14. Tu J. V., Biem H. J., Detsky A. S. Bronchoscopy versus empirical therapy in HIV-infected patients with presumptive Pneumocystis carinii pneumonia. A decision analysis. Am Rev Respir Dis. 1993 Aug;148(2):370–377. doi: 10.1164/ajrccm/148.2.370. [DOI] [PubMed] [Google Scholar]
  15. Vargas S. L., Hughes W. T., Wakefield A. E., Oz H. S. Limited persistence in and subsequent elimination of Pneumocystis carinii from the lungs after P. carinii pneumonia. J Infect Dis. 1995 Aug;172(2):506–510. doi: 10.1093/infdis/172.2.506. [DOI] [PubMed] [Google Scholar]
  16. Wakefield A. E. Detection of DNA sequences identical to Pneumocystis carinii in samples of ambient air. J Eukaryot Microbiol. 1994 Sep-Oct;41(5):116S–116S. [PubMed] [Google Scholar]

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