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. 1991 Jan;35(1):188–191. doi: 10.1128/aac.35.1.188

Comparative in vitro effects of liposomal amphotericin B, amphotericin B-deoxycholate, and free amphotericin B against fungal strains determined by using MIC and minimal lethal concentration susceptibility studies and time-kill curves.

E D Ralph 1, A M Khazindar 1, K R Barber 1, C W Grant 1
PMCID: PMC244966  PMID: 2014976

Abstract

Multilamellar liposomal amphotericin B (L-AmB) was generally less active in vitro against yeast strains than was amphotericin B-deoxycholate or free amphotericin B, although continual agitation of the broth disproportionately increased the activity of L-AmB. Time-kill studies also demonstrated a slower onset of action of L-AmB and supported the hypothesis that liposomes may act as reservoirs for free amphotericin B, which is the active moiety.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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