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. 1991 Jan;35(1):192–194. doi: 10.1128/aac.35.1.192

Comparison of the activity of cefixime and activities of other oral antibiotics against adult clinical isolates of Moraxella (Branhamella) catarrhalis containing BRO-1 and BRO-2 and Haemophilus influenzae.

D R Nash 1, C Flanagan 1, L C Steele 1, R J Wallace Jr 1
PMCID: PMC244967  PMID: 1901696

Abstract

MICs of 10 oral antibiotics were determined for 105 Moraxella catarrhalis and 96 Haemophilus influenzae isolates from adults. A two- to fourfold increase in MICs of oral cephalosporins was seen in the presence of BRO-1 but not with TEM-1 or BRO-2. The MICs of cefixime for 90% of strains of H. influenzae (0.125 microgram/ml) and M. catarrhalis (0.25 microgram/ml) were 8- to 64-fold lower than those of other oral cephalosporins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergeron M. G., Simard P., Provencher P. Influence of growth medium and supplement on growth of Haemophilus influenzae and on antibacterial activity of several antibiotics. J Clin Microbiol. 1987 Apr;25(4):650–655. doi: 10.1128/jcm.25.4.650-655.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown B. A., Wallace R. J., Jr, Flanagan C. W., Wilson R. W., Luman J. I., Redditt S. D. Tetracycline and erythromycin resistance among clinical isolates of Branhamella catarrhalis. Antimicrob Agents Chemother. 1989 Sep;33(9):1631–1633. doi: 10.1128/aac.33.9.1631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fuchs P. C., Jones R. N., Barry A. L., Thornsberry C., Ayers L. W., Gavan T. L., Gerlach E. H. In vitro evaluation of cefixime (FK027, FR17027, CL284635): spectrum against recent clinical isolates, comparative antimicrobial activity, beta-lactamase stability, and preliminary susceptibility testing criteria. Diagn Microbiol Infect Dis. 1986 Jul;5(2):151–162. doi: 10.1016/0732-8893(86)90117-3. [DOI] [PubMed] [Google Scholar]
  4. Jorgensen J. H., Doern G. V., Maher L. A., Howell A. W., Redding J. S. Antimicrobial resistance among respiratory isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae in the United States. Antimicrob Agents Chemother. 1990 Nov;34(11):2075–2080. doi: 10.1128/aac.34.11.2075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jorgensen J. H., Doern G. V., Thornsberry C., Preston D. A., Redding J. S., Maher L. A., Tubert T. Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents. Diagn Microbiol Infect Dis. 1988 Jan;9(1):27–32. doi: 10.1016/0732-8893(88)90057-0. [DOI] [PubMed] [Google Scholar]
  6. Kiani R., Johnson D., Nelson B. Comparative, multicenter studies of cefixime and amoxicillin in the treatment of respiratory tract infections. Am J Med. 1988 Sep 16;85(3A):6–13. doi: 10.1016/0002-9343(88)90457-3. [DOI] [PubMed] [Google Scholar]
  7. Kumar A., Kelly K. J. In vitro activity of cefixime (CL284635) and other antimicrobial agents against Haemophilus isolates from pediatric patients. Chemotherapy. 1988;34(1):30–35. doi: 10.1159/000238544. [DOI] [PubMed] [Google Scholar]
  8. Machka K., Balg H., Braveny I. In vitro activity of new antibiotics against Haemophilus influenzae. Eur J Clin Microbiol Infect Dis. 1988 Dec;7(6):812–814. doi: 10.1007/BF01975058. [DOI] [PubMed] [Google Scholar]
  9. Marshall B., Roberts M., Smith A., Levy S. B. Homogeneity of transferable tetracycline-resistance determinants in Haemophilus species. J Infect Dis. 1984 Jun;149(6):1028–1029. doi: 10.1093/infdis/149.6.1028. [DOI] [PubMed] [Google Scholar]
  10. Mendelman P. M., Henritzy L. L., Chaffin D. O., Lent K., Smith A. L., Stull T. L., Wiley E. A. In vitro activities and targets of three cephem antibiotics against Haemophilus influenzae. Antimicrob Agents Chemother. 1989 Nov;33(11):1878–1882. doi: 10.1128/aac.33.11.1878. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nash D. R., Wallace R. J., Jr, Steingrube V. A., Shurin P. A. Isoelectric focusing of beta-lactamases from sputum and middle ear isolates of Branhamella catarrhalis recovered in the United States. Drugs. 1986;31 (Suppl 3):48–54. doi: 10.2165/00003495-198600313-00012. [DOI] [PubMed] [Google Scholar]
  12. Neu H. C., Chin N. X., Labthavikul P. Comparative in vitro activity and beta-lactamase stability of FR 17027, a new orally active cephalosporin. Antimicrob Agents Chemother. 1984 Aug;26(2):174–180. doi: 10.1128/aac.26.2.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Roberts M. C., Brown B. A., Steingrube V. A., Wallace R. J., Jr Genetic basis of tetracycline resistance in Moraxella (Branhamella) catarrhalis. Antimicrob Agents Chemother. 1990 Sep;34(9):1816–1818. doi: 10.1128/aac.34.9.1816. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wallace R. J., Jr, Steele L. C., Brooks D. L., Forrester G. D., Garcia J. G., Luman J. I., Wilson R. W., Shepherd S., Mclarty J. Ampicillin, tetracycline, and chloramphenicol resistant Haemophilus influenzae in adults with chronic lung disease. Relationship of resistance to prior antimicrobial therapy. Am Rev Respir Dis. 1988 Mar;137(3):695–699. doi: 10.1164/ajrccm/137.3.695. [DOI] [PubMed] [Google Scholar]
  15. Wallace R. J., Jr, Steingrube V. A., Nash D. R., Hollis D. G., Flanagan C., Brown B. A., Labidi A., Weaver R. E. BRO beta-lactamases of Branhamella catarrhalis and Moraxella subgenus Moraxella, including evidence for chromosomal beta-lactamase transfer by conjugation in B. catarrhalis, M. nonliquefaciens, and M. lacunata. Antimicrob Agents Chemother. 1989 Nov;33(11):1845–1854. doi: 10.1128/aac.33.11.1845. [DOI] [PMC free article] [PubMed] [Google Scholar]

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