Abstract
Seventy strains of Clostridium difficile, all isolated from symptomatic patients, were found to be uniformly susceptible to ramoplanin, a new glycolipodepsipeptide antibiotic, and to four glycopeptides (vancomycin, teicoplanin, and two semisynthetic teicoplanin derivatives). Ramoplanin is recommended for further evaluation in the treatment of C. difficile-associated disease.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bartlett J. G., Chang T. W., Gurwith M., Gorbach S. L., Onderdonk A. B. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978 Mar 9;298(10):531–534. doi: 10.1056/NEJM197803092981003. [DOI] [PubMed] [Google Scholar]
- Bartlett J. G. Clostridium difficile: clinical considerations. Rev Infect Dis. 1990 Jan-Feb;12 (Suppl 2):S243–S251. doi: 10.1093/clinids/12.supplement_2.s243. [DOI] [PubMed] [Google Scholar]
- Bartlett J. G. Treatment of Clostridium difficile colitis. Gastroenterology. 1985 Nov;89(5):1192–1195. doi: 10.1016/0016-5085(85)90227-6. [DOI] [PubMed] [Google Scholar]
- Cavalleri B., Pagani H., Volpe G., Selva E., Parenti F. A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics. J Antibiot (Tokyo) 1984 Apr;37(4):309–317. doi: 10.7164/antibiotics.37.309. [DOI] [PubMed] [Google Scholar]
- Ciabatti R., Kettenring J. K., Winters G., Tuan G., Zerilli L., Cavalleri B. Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation. J Antibiot (Tokyo) 1989 Feb;42(2):254–267. doi: 10.7164/antibiotics.42.254. [DOI] [PubMed] [Google Scholar]
- Dixson S., Brumfitt W., Hamilton-Miller J. M. In vitro evaluation of ramoplanin (MDL 62198, A 16686) Eur J Clin Microbiol Infect Dis. 1988 Dec;7(6):819–821. doi: 10.1007/BF01975062. [DOI] [PubMed] [Google Scholar]
- Fekety R., Silva J., Buggy B., Deery H. G. Treatment of antibiotic-associated colitis with vancomycin. J Antimicrob Chemother. 1984 Dec;14 (Suppl 500):97–102. doi: 10.1093/jac/14.suppl_d.97. [DOI] [PubMed] [Google Scholar]
- George R. H., Symonds J. M., Dimock F., Brown J. D., Arabi Y., Shinagawa N., Keighley M. R., Alexander-Williams J., Burdon D. W. Identification of Clostridium difficile as a cause of pseudomembranous colitis. Br Med J. 1978 Mar 18;1(6114):695–695. doi: 10.1136/bmj.1.6114.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gurusiddaiah S., Graham S. O. Some chemical and physical characteristics of pantomycin, and antiobiotic isolated from Streptomyces hygroscopicus. Antimicrob Agents Chemother. 1980 Jun;17(6):980–987. doi: 10.1128/aac.17.6.980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jorgensen J. H., Redding J. S., Maher L. A. Antibacterial activity of the new glycopeptide antibiotic SKF104662. Antimicrob Agents Chemother. 1989 Apr;33(4):560–561. doi: 10.1128/aac.33.4.560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaplan A. H., Gilligan P. H., Facklam R. R. Recovery of resistant enterococci during vancomycin prophylaxis. J Clin Microbiol. 1988 Jun;26(6):1216–1218. doi: 10.1128/jcm.26.6.1216-1218.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Larson H. E., Price A. B., Honour P., Borriello S. P. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet. 1978 May 20;1(8073):1063–1066. doi: 10.1016/s0140-6736(78)90912-1. [DOI] [PubMed] [Google Scholar]
- Malabarba A., Trani A., Strazzolini P., Cietto G., Ferrari P., Tarzia G., Pallanza R., Berti M. Synthesis and biological properties of N63-carboxamides of teicoplanin antibiotics. Structure-activity relationships. J Med Chem. 1989 Nov;32(11):2450–2460. doi: 10.1021/jm00131a007. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Neu N. M. In vitro activity of A-16686, a new glycopeptide. Chemotherapy. 1986;32(5):453–457. doi: 10.1159/000238450. [DOI] [PubMed] [Google Scholar]
- Pallanza R., Berti M., Scotti R., Randisi E., Arioli V. A-16686, a new antibiotic from Actinoplanes. II. Biological properties. J Antibiot (Tokyo) 1984 Apr;37(4):318–324. doi: 10.7164/antibiotics.37.318. [DOI] [PubMed] [Google Scholar]
- Pallanza R., Scotti R., Beretta G., Cavalleri B., Arioli V. In vitro activity of A-16686, a potential antiplaque agent. Antimicrob Agents Chemother. 1984 Oct;26(4):462–465. doi: 10.1128/aac.26.4.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shlaes D. M., Al-Obeid S., Shlaes J. H., Williamson R. Activity of various glycopeptides against an inducibly vancomycin-resistant strain of Enterococcus faecium (D366). J Infect Dis. 1989 Jun;159(6):1132–1135. doi: 10.1093/infdis/159.6.1132. [DOI] [PubMed] [Google Scholar]
- Shlaes D. M., Binczewski B. Enterococcal resistance to vancomycin and related cyclic glycopeptide antibiotics. Eur J Clin Microbiol Infect Dis. 1990 Feb;9(2):106–110. doi: 10.1007/BF01963634. [DOI] [PubMed] [Google Scholar]
- Somner E. A., Reynolds P. E. Inhibition of peptidoglycan biosynthesis by ramoplanin. Antimicrob Agents Chemother. 1990 Mar;34(3):413–419. doi: 10.1128/aac.34.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Uttley A. H., Collins C. H., Naidoo J., George R. C. Vancomycin-resistant enterococci. Lancet. 1988 Jan 2;1(8575-6):57–58. doi: 10.1016/s0140-6736(88)91037-9. [DOI] [PubMed] [Google Scholar]
- Varaldo P. E., Debbia E., Schito G. C. In vitro activity of teichomycin and vancomycin alone and in combination with rifampin. Antimicrob Agents Chemother. 1983 Mar;23(3):402–406. doi: 10.1128/aac.23.3.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Lalla F., Privitera G., Rinaldi E., Ortisi G., Santoro D., Rizzardini G. Treatment of Clostridium difficile-associated disease with teicoplanin. Antimicrob Agents Chemother. 1989 Jul;33(7):1125–1127. doi: 10.1128/aac.33.7.1125. [DOI] [PMC free article] [PubMed] [Google Scholar]