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. 1991 Jan;35(1):208–210. doi: 10.1128/aac.35.1.208

Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery.

G Privitera 1, P Scarpellini 1, G Ortisi 1, G Nicastro 1, R Nicolin 1, F de Lalla 1
PMCID: PMC244972  PMID: 2014978

Abstract

A total of 108 volunteers undergoing an elective surgical procedure were randomly given a single 2-g intravenous prophylactic dose of either a cephalosporin or mezlocillin. Stool samples were cultured for Clostridium difficile the day before the operation and later on postoperative days 4, 7, and 14. C. difficile was detected in 23.0% of patients who received a cephalosporin (cefoxitin, 8.3%; cefazolin, 14.3%; cefotetan, 20.0%; ceftriaxone, 25.0%; cefoperazone, 43.7%), in 3.3% of patients given mezlocillin, and in none of 15 control volunteers given no antimicrobial agent. No patient experienced diarrhea.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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