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. 1991 Feb;35(2):277–282. doi: 10.1128/aac.35.2.277

8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models.

M S Bartlett 1, S F Queener 1, R R Tidwell 1, W K Milhous 1, J D Berman 1, W Y Ellis 1, J W Smith 1
PMCID: PMC244991  PMID: 2024961

Abstract

Three 8-aminoquinolines from the Walter Reed Army Institute for Research (WRAIR), WR6026, WR238605, and WR242511, strongly inhibited Pneumocystis carinii growth in vitro at 1 microgram/ml. This activity was similar to that of primaquine. In rat therapy models, the WRAIR compounds affected Pneumocystis pneumonia at doses as low as 0.25 mg/kg (WR242511) or 0.5 mg/kg (WR6026 and WR238605). At these doses, primaquine alone was ineffective as therapy. In a rat prophylaxis model, all three WRAIR 8-aminoquinolines were extremely effective at daily doses of 0.57 mg/kg, showing activity greater than that of primaquine at this dosage and comparable to that of trimethoprim-sulfamethoxazole at 50/250 mg/kg.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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