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. 1991 Feb;35(2):394–397. doi: 10.1128/aac.35.2.394

Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis.

T Yokota 1, S Mochizuki 1, K Konno 1, S Mori 1, S Shigeta 1, E De Clercq 1
PMCID: PMC245016  PMID: 2024975

Abstract

By using an assay system based on a human hepatoblastoma cell line (HB611) that continuously synthesizes hepatitis B virus DNA, the following compounds were found to inhibit hepatitis B virus DNA synthesis at concentrations that were significantly lower than their minimum cytotoxic concentrations: 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(phosphonylmethoxyethyl)adenine, 2',3'-dideoxy-2',3'-didehydrocytidine, and 2',3'-dideoxycytidine. The most potent compound was PMEDAP (50% effective concentration, 0.02 micrograms/ml). The selective index, or ratio of the 50% cytotoxic concentration to 50% effective concentration, of PMEDAP was greater than 750.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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