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. 1991 Mar;35(3):572–574. doi: 10.1128/aac.35.3.572

Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.

H Tsiang 1, P E Ceccaldi 1, A Ermine 1, B Lockhart 1, S Guillemer 1
PMCID: PMC245052  PMID: 1674849

Abstract

A noncompetitive N-methyl-D-aspartate (NMDA) antagonist, MK-801 (0.5 to 2.0 mM), inhibits rabies virus infection in rat primary cortical neurons, whereas the competitive NMDA antagonist AP5 has no effect. The results suggest that MK-801-mediated inhibition of rabies virus replication, although selective, is not operating through the high-affinity binding site mechanism.

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Selected References

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  1. Aguayo L. G., Albuquerque E. X. Phencyclidine blocks two potassium currents in spinal neurons in cell culture. Brain Res. 1987 Dec 8;436(1):9–17. doi: 10.1016/0006-8993(87)91550-2. [DOI] [PubMed] [Google Scholar]
  2. Anis N. A., Berry S. C., Burton N. R., Lodge D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br J Pharmacol. 1983 Jun;79(2):565–575. doi: 10.1111/j.1476-5381.1983.tb11031.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Choi D. W., Koh J. Y., Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci. 1988 Jan;8(1):185–196. doi: 10.1523/JNEUROSCI.08-01-00185.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Foster A. C., Gill R., Woodruff G. N. Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. J Neurosci. 1988 Dec;8(12):4745–4754. doi: 10.1523/JNEUROSCI.08-12-04745.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gill R., Foster A. C., Woodruff G. N. MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period. Neuroscience. 1988 Jun;25(3):847–855. doi: 10.1016/0306-4522(88)90040-1. [DOI] [PubMed] [Google Scholar]
  6. Gourmelon P., Briet D., Court L., Tsiang H. Electrophysiological and sleep alterations in experimental mouse rabies. Brain Res. 1986 Nov 19;398(1):128–140. doi: 10.1016/0006-8993(86)91258-8. [DOI] [PubMed] [Google Scholar]
  7. Greenamyre J. T., Penney J. B., D'Amato C. J., Young A. B. Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding. J Neurochem. 1987 Feb;48(2):543–551. doi: 10.1111/j.1471-4159.1987.tb04127.x. [DOI] [PubMed] [Google Scholar]
  8. Klockgether T., Turski L. Excitatory amino acids and the basal ganglia: implications for the therapy of Parkinson's disease. Trends Neurosci. 1989 Aug;12(8):285–286. doi: 10.1016/0166-2236(89)90007-6. [DOI] [PubMed] [Google Scholar]
  9. Koschel K., Halbach M. Rabies virus infection selectively impairs membrane receptor functions in neuronal model cells. J Gen Virol. 1979 Mar;42(3):627–632. doi: 10.1099/0022-1317-42-3-627. [DOI] [PubMed] [Google Scholar]
  10. Koschel K., Münzel P. Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells. Proc Natl Acad Sci U S A. 1984 Feb;81(3):950–954. doi: 10.1073/pnas.81.3.950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lycke E., Tsiang H. Rabies virus infection of cultured rat sensory neurons. J Virol. 1987 Sep;61(9):2733–2741. doi: 10.1128/jvi.61.9.2733-2741.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McDonald J. W., Silverstein F. S., Johnston M. V. MK-801 protects the neonatal brain from hypoxic-ischemic damage. Eur J Pharmacol. 1987 Aug 21;140(3):359–361. doi: 10.1016/0014-2999(87)90295-0. [DOI] [PubMed] [Google Scholar]
  13. McGeer E. G., McGeer P. L. Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids. Nature. 1976 Oct 7;263(5577):517–519. doi: 10.1038/263517a0. [DOI] [PubMed] [Google Scholar]
  14. Murphy F. A. Rabies pathogenesis. Arch Virol. 1977;54(4):279–297. doi: 10.1007/BF01314774. [DOI] [PubMed] [Google Scholar]
  15. Olney J., Price M., Salles K. S., Labruyere J., Frierdich G. MK-801 powerfully protects against N-methyl aspartate neurotoxicity. Eur J Pharmacol. 1987 Sep 23;141(3):357–361. doi: 10.1016/0014-2999(87)90552-8. [DOI] [PubMed] [Google Scholar]
  16. Rondouin G., Drian M. J., Chicheportiche R., Kamenka J. M., Privat A. Non-competitive antagonists of N-methyl-D-aspartate receptors protect cortical and hippocampal cell cultures against glutamate neurotoxicity. Neurosci Lett. 1988 Aug 31;91(2):199–203. doi: 10.1016/0304-3940(88)90768-9. [DOI] [PubMed] [Google Scholar]
  17. Rothman S. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J Neurosci. 1984 Jul;4(7):1884–1891. doi: 10.1523/JNEUROSCI.04-07-01884.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Takara H., Wada A., Arita M., Sumikawa K., Izumi F. Ketamine inhibits 45Ca influx and catecholamine secretion by inhibiting 22Na influx in cultured bovine adrenal medullary cells. Eur J Pharmacol. 1986 Jun 17;125(2):217–224. doi: 10.1016/0014-2999(86)90030-0. [DOI] [PubMed] [Google Scholar]
  19. Tsiang H., Koulakoff A., Bizzini B., Berwald-Netter Y. Neurotropism of rabies virus. An in vitro study. J Neuropathol Exp Neurol. 1983 Jul;42(4):439–452. doi: 10.1097/00005072-198307000-00006. [DOI] [PubMed] [Google Scholar]
  20. Wong E. H., Kemp J. A., Priestley T., Knight A. R., Woodruff G. N., Iversen L. L. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104–7108. doi: 10.1073/pnas.83.18.7104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Zorumski C. F., Yang J. Non-competitive inhibition of GABA currents by phenothiazines in cultured chick spinal cord and rat hippocampal neurons. Neurosci Lett. 1988 Sep 23;92(1):86–91. doi: 10.1016/0304-3940(88)90747-1. [DOI] [PubMed] [Google Scholar]

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