Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1991 Mar;35(3):582–583. doi: 10.1128/aac.35.3.582

In vitro synergy studies with Clostridium difficile.

A E Bacon 1, S McGrath 1, R Fekety 1, W J Holloway 1
PMCID: PMC245055  PMID: 2039211

Abstract

Agar dilution anaerobic susceptibility studies using rifampin, vancomycin, metronidazole, and bacitracin individually and in combination were performed with Clostridium difficile. Fifty-five strains of C. difficile were studied. Eighty-five percent of strains tested (29 of 34) were synergistically inhibited by the combination of bacitracin and rifampin (fractional inhibitory concentration, less than or equal to 0.50).

Full text

PDF
582

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buggy B. P., Fekety R., Silva J., Jr Therapy of relapsing Clostridium difficile-associated diarrhea and colitis with the combination of vancomycin and rifampin. J Clin Gastroenterol. 1987 Apr;9(2):155–159. doi: 10.1097/00004836-198704000-00009. [DOI] [PubMed] [Google Scholar]
  2. Chang T. W., Lauermann M., Bartlett J. G. Cytotoxicity assay in antibiotic-associated colitis. J Infect Dis. 1979 Nov;140(5):765–770. doi: 10.1093/infdis/140.5.765. [DOI] [PubMed] [Google Scholar]
  3. Dudley M. N., McLaughlin J. C., Carrington G., Frick J., Nightingale C. H., Quintiliani R. Oral bacitracin vs vancomycin therapy for Clostridium difficile-induced diarrhea. A randomized double-blind trial. Arch Intern Med. 1986 Jun;146(6):1101–1104. [PubMed] [Google Scholar]
  4. ELION G. B., SINGER S., HITCHINGS G. H. Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. J Biol Chem. 1954 Jun;208(2):477–488. [PubMed] [Google Scholar]
  5. Fekety R., Silva J., Kauffman C., Buggy B., Deery H. G. Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimens. Am J Med. 1989 Jan;86(1):15–19. doi: 10.1016/0002-9343(89)90223-4. [DOI] [PubMed] [Google Scholar]
  6. Hall M. J., Middleton R. F., Westmacott D. The fractional inhibitory concentration (FIC) index as a measure of synergy. J Antimicrob Chemother. 1983 May;11(5):427–433. doi: 10.1093/jac/11.5.427. [DOI] [PubMed] [Google Scholar]
  7. Silva J., Jr, Batts D. H., Fekety R., Plouffe J. F., Rifkin G. D., Baird I. Treatment of Clostridium difficile colitis and diarrhea with vancomycin. Am J Med. 1981 Nov;71(5):815–822. doi: 10.1016/0002-9343(81)90369-7. [DOI] [PubMed] [Google Scholar]
  8. Teasley D. G., Gerding D. N., Olson M. M., Peterson L. R., Gebhard R. L., Schwartz M. J., Lee J. T., Jr Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis. Lancet. 1983 Nov 5;2(8358):1043–1046. doi: 10.1016/s0140-6736(83)91036-x. [DOI] [PubMed] [Google Scholar]
  9. Tvede M., Rask-Madsen J. Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients. Lancet. 1989 May 27;1(8648):1156–1160. doi: 10.1016/s0140-6736(89)92749-9. [DOI] [PubMed] [Google Scholar]
  10. Young G. P., Ward P. B., Bayley N., Gordon D., Higgins G., Trapani J. A., McDonald M. I., Labrooy J., Hecker R. Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin. Gastroenterology. 1985 Nov;89(5):1038–1045. doi: 10.1016/0016-5085(85)90206-9. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES