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. 1991 Apr;35(4):750–752. doi: 10.1128/aac.35.4.750

Loracarbef versus cefaclor in the treatment of urinary tract infections in women.

A Iravani 1
PMCID: PMC245091  PMID: 2069382

Abstract

In a double-blind, prospective, randomized study, 108 college women with acute urinary tract infections were treated for 7 days with either loracarbef (LY163892) at 200 mg once daily (n = 53) or cefaclor at 250 mg three times daily (n = 55). The cure rates at 5 to 9 days after treatment in the loracarbef and cefaclor groups were 96 and 90%, respectively. Both loracarbef and cefaclor are safe, well tolerated, and effective in the treatment of urinary tract infections in women.

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Selected References

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  1. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  2. Bill N. J., Washington J. A., 2nd Comparison of in vitro activity of cephalexin, cephradine, and cefaclor. Antimicrob Agents Chemother. 1977 Mar;11(3):470–474. doi: 10.1128/aac.11.3.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CUTLER S. J., EDERER F. Maximum utilization of the life table method in analyzing survival. J Chronic Dis. 1958 Dec;8(6):699–712. doi: 10.1016/0021-9681(58)90126-7. [DOI] [PubMed] [Google Scholar]
  4. Cao C., Chin N. X., Neu H. C. In-vitro activity and beta-lactamase stability of LY163892. J Antimicrob Chemother. 1988 Aug;22(2):155–165. doi: 10.1093/jac/22.2.155. [DOI] [PubMed] [Google Scholar]
  5. Gurwith M. J., Stein G. E., Gurwith D. Prospective comparison of amoxicillin-clavulanic acid and cefaclor in treatment of uncomplicated urinary tract infections. Antimicrob Agents Chemother. 1983 Nov;24(5):716–719. doi: 10.1128/aac.24.5.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Howard A. J., Dunkin K. T. Comparative in-vitro activity of a new oral carbacephem, LY163892. J Antimicrob Chemother. 1988 Oct;22(4):445–456. doi: 10.1093/jac/22.4.445. [DOI] [PubMed] [Google Scholar]
  7. Iravani A., Pryor N., Richard G. A. Treatment of acute uncomplicated urinary tract infections by cephalexin, with special reference to the antibody-coated bacteria. Int J Clin Pharmacol Ther Toxicol. 1982 Mar;20(3):97–100. [PubMed] [Google Scholar]
  8. Iravani A., Richard G. A. Amoxicillin-clavulanic acid versus cefaclor in the treatment of urinary tract infections and their effects on the urogenital and rectal flora. Antimicrob Agents Chemother. 1986 Jan;29(1):107–111. doi: 10.1128/aac.29.1.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Iravani A., Richard G. A., Baer H. Treatment of uncomplicated urinary tract infections with trimethoprim versus sulfisoxazole, with special reference to antibody-coated bacteria and fecal flora. Antimicrob Agents Chemother. 1981 May;19(5):842–850. doi: 10.1128/aac.19.5.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Iravani A., Richard G. A., Johnson D., Bryant A. A double-blind, multicenter, comparative study of the safety and efficacy of cefixime versus amoxicillin in the treatment of acute urinary tract infections in adult patients. Am J Med. 1988 Sep 16;85(3A):17–23. doi: 10.1016/0002-9343(88)90459-7. [DOI] [PubMed] [Google Scholar]
  11. Iravani A., Richard G. A. Single-dose cefuroxime axetil versus multiple-dose cefaclor in the treatment of acute urinary tract infections. Antimicrob Agents Chemother. 1989 Aug;33(8):1212–1216. doi: 10.1128/aac.33.8.1212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Iravani A., Richard G. A. Treatment of urinary tract infections with a combination of amoxicillin and clavulanic acid. Antimicrob Agents Chemother. 1982 Oct;22(4):672–677. doi: 10.1128/aac.22.4.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jones R. N., Barry A. L. Antimicrobial activity of LY163892, an orally administered 1-carbacephem. J Antimicrob Chemother. 1988 Sep;22(3):315–320. doi: 10.1093/jac/22.3.315. [DOI] [PubMed] [Google Scholar]
  14. Jordan P. A., Iravani A., Richard G. A., Baer H. Urinary tract infection caused by Staphylococcus saprophyticus. J Infect Dis. 1980 Oct;142(4):510–515. doi: 10.1093/infdis/142.4.510. [DOI] [PubMed] [Google Scholar]
  15. Knapp C. C., Washington J. A., 2nd In vitro activities of LY163892, cefaclor, and cefuroxime. Antimicrob Agents Chemother. 1988 Jan;32(1):131–133. doi: 10.1128/aac.32.1.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Nelson J. D., Shelton S., Kusmiesz H. Pharmacokinetics of LY163892 in infants and children. Antimicrob Agents Chemother. 1988 Nov;32(11):1738–1739. doi: 10.1128/aac.32.11.1738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Orskov I., Orskov F., Jann B., Jann K. Serology, chemistry, and genetics of O and K antigens of Escherichia coli. Bacteriol Rev. 1977 Sep;41(3):667–710. doi: 10.1128/br.41.3.667-710.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rotschafer J., Crossley K., Zaske D., Viste R. Comparative study of cefaclor and amoxicillin in treatment of urinary tract infection. Urology. 1979 Sep;14(3):233–236. doi: 10.1016/0090-4295(79)90489-8. [DOI] [PubMed] [Google Scholar]
  19. Rous S. N. A comparison of cefaclor versus trimethoprim-sulfamethoxazole combination in the treatment of acute urinary infections. J Urol. 1981 Feb;125(2):228–229. doi: 10.1016/s0022-5347(17)54981-2. [DOI] [PubMed] [Google Scholar]
  20. Smith P. B., Tomfohrde K. M., Rhoden D. L., Balows A. API system: a multitube micromethod for identification of Enterobacteriaceae. Appl Microbiol. 1972 Sep;24(3):449–452. doi: 10.1128/am.24.3.449-452.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Williams K. J., Hebblethwaite E. M., Brown G. W., Cox D. M., Plested S. J. Cefuroxime axetil in the treatment of uncomplicated UTI: a comparison with cefaclor and augmentin. Drugs Exp Clin Res. 1987;13(2):95–99. [PubMed] [Google Scholar]

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