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. 1991 May;35(5):988–991. doi: 10.1128/aac.35.5.988

Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs.

R Rooke 1, M A Parniak 1, M Tremblay 1, H Soudeyns 1, X G Li 1, Q Gao 1, X J Yao 1, M A Wainberg 1
PMCID: PMC245142  PMID: 1649576

Abstract

We used a viral endpoint dilution assay to show changes in the proportion of zidovudine (azidothymidine; AZT)-resistant viruses within a heterogeneous mixture of human immunodeficiency virus type 1 (HIV-1) quasispecies isolated from patients on long-term AZT therapy. Several HIV-1 isolates, which could replicate in 10 microM AZT, were susceptible to both 2',3'-dideoxycytidine and a novel cytosine analog BCH-189, in which a sulfur atom replaces the 3' carbon of the pentose ring. In certain instances, cross-resistance was seen with 3'-didehydro-2',3'-dideoxythymidine. Although most strains of AZT-resistant HIV-1 displayed reduced susceptibility to 3'-azido-2',3'-dideoxyuridine, two strains were identified for which this was not the case.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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