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. 1991 Jul;35(7):1329–1333. doi: 10.1128/aac.35.7.1329

Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis.

D W Denning 1, D A Stevens 1
PMCID: PMC245166  PMID: 1929289

Abstract

Cilofungin, amphotericin B, and a combination of the two drugs were compared in a model of aspergillosis in immunocompetent mice in three experiments. Cilofungin was equivalent to amphotericin B in preventing death and eradicating cerebral aspergillosis, but it did not sterilize the kidneys. This is the first demonstration of the in vivo activity of cilofungin against any fungus other than Candida albicans. The mortality with combination therapy was higher than those with amphotericin B alone (P = 0.003) and cilofungin alone (P = 0.054), as was weight loss after infection, indicating antagonism between cilofungin and amphotericin B in this model. The mechanisms of action and antagonism remain to be explained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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