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. 1991 Jul;35(7):1430–1433. doi: 10.1128/aac.35.7.1430

Synergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitro.

M Baba 1, M Ito 1, S Shigeta 1, H Tanaka 1, T Miyasaka 1, M Ubasawa 1, K Umezu 1, R T Walker 1, E De Clercq 1
PMCID: PMC245184  PMID: 1929304

Abstract

A novel 6-substituted acyclouridine derivative, 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU), has recently proved to be a highly potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro. Combinations of 3'-azido-2',3'-dideoxythymidine (AZT) and E-EPU synergistically inhibit the replication of HIV-1 in MT-4 cells, whereas the cytotoxic effects of AZT and E-EPU on mock-infected MT-4 cells are not enhanced by the drug combination. Synergistic inhibition of HIV-1 replication has also been observed in peripheral blood lymphocytes. These results indicate that the combination of AZT and E-EPU should be further pursued in the treatment of AIDS.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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