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. 1991 Jul;35(7):1486–1488. doi: 10.1128/aac.35.7.1486

Measurement of the concentration of amphotericin B in brain tissue of scrapie-infected hamsters with a simple and sensitive method.

P Casaccia 1, A Ladogana 1, Y G Xi 1, L Ingrosso 1, M Pocchiari 1, M C Silvestrini 1, A Cittadini 1
PMCID: PMC245196  PMID: 1929313

Abstract

A simple, sensitive, and reproducible assay for the measurement of the amphotericin B concentration in tissue extracts was developed by using the fourth derivative of the absorption spectrum of amphotericin B between wavelengths of 330 and 430 nm. The amphotericin B concentration in spleen and brain was proportional to the total amount administered. The amphotericin B concentration in the brain was highly correlated with the increase in the mean incubation period of intracerebrally scrapie-infected hamsters.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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