Abstract
The efficacies of 40 mg of ofloxacin per kg/day given orally and 250 mg of penicillin per kg/day given intramuscularly, alone or in combination, were evaluated in the prevention of mortality of C3H/HeN female mice given 8.2 Gy of 60Co radiation. Mortalities were 51 of 60 mice (85%) in the control group, 46 of 60 mice (77%) among those treated with penicillin, 32 of 60 mice (53%) among those treated with ofloxacin (P less than 0.05), and 5 of 60 mice (8%) among those treated with ofloxacin and penicillin (P less than 0.001). The organisms recovered from the livers of control mice were members of the family Enterobacteriaceae and Streptococcus spp. A reduction in the number of the Enterobacteriaceae was noted only in ofloxacin-treated mice, and a reduction in the number of Streptococcus spp. was noted only in the penicillin-treated mice. Reductions in the numbers of both groups of organisms were noted only in the animals treated with both agents. This study shows the advantage of the combination of ofloxacin and penicillin in the prevention of bacterial translocation and animal mortality after irradiation.
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- Bauernfeind A., Petermüller C. In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid. Eur J Clin Microbiol. 1983 Apr;2(2):111–115. doi: 10.1007/BF02001575. [DOI] [PubMed] [Google Scholar]
- Brook I., Elliott T. B., Ledney G. D. Quinolone therapy of Klebsiella pneumoniae sepsis following irradiation: comparison of pefloxacin, ciprofloxacin, and ofloxacin. Radiat Res. 1990 May;122(2):215–217. [PubMed] [Google Scholar]
- Brook I., Ledney G. D. Oral ofloxacin therapy of Pseudomonas aeruginosa sepsis in mice after irradiation. Antimicrob Agents Chemother. 1990 Jul;34(7):1387–1389. doi: 10.1128/aac.34.7.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brook I., MacVittie T. J., Walker R. I. Recovery of aerobic and anaerobic bacteria from irradiated mice. Infect Immun. 1984 Oct;46(1):270–271. doi: 10.1128/iai.46.1.270-271.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brook I., Walker R. I., MacVittie T. J. Effect of antimicrobial therapy on bowel flora and bacterial infection in irradiated mice. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 May;53(5):709–716. doi: 10.1080/09553008814551081. [DOI] [PubMed] [Google Scholar]
- KAPLAN H. S., SPECK R. S., JAWETZ E. Impairment of antimicrobial defense following total body irradiation of mice. J Lab Clin Med. 1952 Nov;40(5):682–691. [PubMed] [Google Scholar]
- Kelsey S. M., Wood M. E., Shaw E., Newland A. C. Intravenous ciprofloxacin as empirical treatment of febrile neutropenic patients. Am J Med. 1989 Nov 30;87(5A):274S–277S. doi: 10.1016/0002-9343(89)90079-x. [DOI] [PubMed] [Google Scholar]
- Pecquet S., Andremont A., Tancrède C. Selective antimicrobial modulation of the intestinal tract by norfloxacin in human volunteers and in gnotobiotic mice associated with a human fecal flora. Antimicrob Agents Chemother. 1986 Jun;29(6):1047–1052. doi: 10.1128/aac.29.6.1047. [DOI] [PMC free article] [PubMed] [Google Scholar]