Abstract
Chlorpromazine (CPZ), at a concentration of 60 micrograms/ml of medium completely inhibited the replication of Escherichia coli. At concentrations below this MIC, CPZ caused transient induction of filamentation, such that by the end of 5 h, all of the cells were filaments, and by the end of 24 h, only rod-shaped E. coli were present. The reversion to normal morphology in the presence of CPZ was not due to either the degradation of CPZ or the selection of CPZ-resistant mutants. The electrophoretic pattern of proteins extracted from isolated cell envelopes of CPZ-induced filaments as well as from E. coli that reverted to normal morphology was distinctly different from that of the controls.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Amaral L., Lee Y., Schwarz U., Lorian V. Penicillin-binding site on the Escherichia coli cell envelope. J Bacteriol. 1986 Aug;167(2):492–495. doi: 10.1128/jb.167.2.492-495.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BOURDON J. L. [Contribution to the study of the antibiotic properties of chlorpromazine or 4560 RP]. Ann Inst Pasteur (Paris) 1961 Dec;101:876–886. [PubMed] [Google Scholar]
- Kristiansen J. E. Dyes, antipsychotic drugs, and antimicrobial activity. Fragments of a development, with special reference to the influence of Paul Ehrlich. Dan Med Bull. 1989 Apr;36(2):178–185. [PubMed] [Google Scholar]
- Kristiansen J. E. Experiments to illustrate the effect of chlorpromazine on the permeability of the bacterial cell wall. Acta Pathol Microbiol Scand B. 1979 Oct;87(5):317–319. doi: 10.1111/j.1699-0463.1979.tb02445.x. [DOI] [PubMed] [Google Scholar]
- POPPER M., LORIAN V. L'action de la chlorpromazine sur les microbes et le complexe bactériostatique in vitro. Presse Med. 1959 Jan 31;67(6):212–212. [PubMed] [Google Scholar]
- Varley M. A., Atkinson T., Ross L. N. The effect of lactation length on the circulating concentrations of progesterone and oestradiol in the early weaned sow. Theriogenology. 1981 Aug;16(2):179–184. doi: 10.1016/0093-691x(81)90099-6. [DOI] [PubMed] [Google Scholar]