Abstract
The in vivo interactions of cilofungin, an echinocandin antifungal agent, and amphotericin B, a polyene derivative, in a murine model of disseminated candidiasis have been investigated. While single therapy with either drug alone prolonged survival of infected mice, kidney colony counts were not appreciably reduced. In contrast, combination therapy, especially at higher doses of both drugs, resulted in significant prolongation of survival and suppression of growth of yeast cells in the kidneys. Combination therapy of experimental candidiasis with cilofungin and amphotericin B did not result in antagonism; rather, additive or synergistic effects were seen. Future preclinical work with other echinocandin and polyene derivatives should include studies evaluating the in vivo interactions of both classes of compounds.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bulo A. N., Bradley S. F., Kauffman C. A. The effect of cilofungin (LY 121019) in combination with amphotericin B or flucytosine against Candida species. Mycoses. 1989 Mar;32(3):151–157. doi: 10.1111/j.1439-0507.1989.tb02224.x. [DOI] [PubMed] [Google Scholar]
- Galgiani J. N. Antifungal susceptibility tests. Antimicrob Agents Chemother. 1987 Dec;31(12):1867–1870. doi: 10.1128/aac.31.12.1867. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hall G. S., Myles C., Pratt K. J., Washington J. A. Cilofungin (LY121019), an antifungal agent with specific activity against Candida albicans and Candida tropicalis. Antimicrob Agents Chemother. 1988 Sep;32(9):1331–1335. doi: 10.1128/aac.32.9.1331. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hanson L. H., Perlman A. M., Clemons K. V., Stevens D. A. Synergy between cilofungin and amphotericin B in a murine model of candidiasis. Antimicrob Agents Chemother. 1991 Jul;35(7):1334–1337. doi: 10.1128/aac.35.7.1334. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morrison C. J., Stevens D. A. Comparative effects of cilofungin and amphotericin B on experimental murine candidiasis. Antimicrob Agents Chemother. 1990 May;34(5):746–750. doi: 10.1128/aac.34.5.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Odds F. C. Activity of cilofungin (LY121019) against Candida species in vitro. J Antimicrob Chemother. 1988 Dec;22(6):891–897. doi: 10.1093/jac/22.6.891. [DOI] [PubMed] [Google Scholar]
- Picard M., Meshulam T., Sugar A. M. In vitro activity of LY121019 against Candida species and Torulopsis glabrata. Eur J Clin Microbiol Infect Dis. 1988 Jun;7(3):432–433. doi: 10.1007/BF01962358. [DOI] [PubMed] [Google Scholar]
- Smith K. R., Lank K. M., Cobbs C. G., Cloud G. A., Dismukes W. E. Comparison of cilofungin and amphotericin B for therapy of murine candidiasis. Antimicrob Agents Chemother. 1990 Aug;34(8):1619–1621. doi: 10.1128/aac.34.8.1619. [DOI] [PMC free article] [PubMed] [Google Scholar]