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. 1991 Oct;35(10):2155–2158. doi: 10.1128/aac.35.10.2155

Increased resistance to multiple drugs by introduction of the Enterobacter cloacae romA gene into OmpF porin-deficient mutants of Escherichia coli K-12.

T Komatsu 1, M Ohta 1, N Kido 1, Y Arakawa 1, H Ito 1, N Kato 1
PMCID: PMC245346  PMID: 1662028

Abstract

Introduction of the romA gene cloned from Enterobacter cloacae into Escherichia coli K-12 resulted in almost complete inhibition of OmpF expression and a concomitant increase in resistance to quinolones, beta-lactams, chloramphenicol, and tetracyclines. In addition, the romA gene reduced the susceptibility to these multiple drugs even in the OmpF porin-deficient mutants of E. coli K-12. Results indicate the presence of romA-sensitive penetration pathway(s) for these multiple drugs other than the OmpF porin in E. coli.

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Selected References

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