Abstract
After 3 days of treatment with ofloxacin (300 mg given orally once daily), the drug levels in serum and pleural fluid 2 and 4 h after drug administration in patients with tuberculous pleural effusion were assessed by a rapid high-performance liquid chromatography assay. The levels in serum (mean +/- standard error of the mean [SEM]) were 4.70 +/- 0.14 and 4.63 +/- 0.09 mg/liter 2 and 4 h after administration, respectively, and the levels in pleural fluid (mean +/- SEM) were 3.82 +/- 0.09 and 4.21 +/- 0.08 mg/liter, respectively. The pleural fluid-to-serum ofloxacin ratio at 2 h was 0.82 +/- 0.02 (mean +/- SEM), and the ratio at 4 h was 0.92 +/- 0.02 (mean +/- SEM). This study demonstrated very good penetration of ofloxacin into pleural fluid in tuberculous pleuritis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ABRAMS W. B., SMALL M. J. Current concepts of tuberculous pleurisy with effusion as derived from pleural biopsy studies. Dis Chest. 1960 Jul;38:60–65. doi: 10.1378/chest.38.1.60. [DOI] [PubMed] [Google Scholar]
- Berger H. W., Mejia E. Tuberculous pleurisy. Chest. 1973 Jan;63(1):88–92. doi: 10.1378/chest.63.1.88. [DOI] [PubMed] [Google Scholar]
- Chan C. Y., Lam A. W., French G. L. Rapid HPLC assay of fluoroquinolones in clinical specimens. J Antimicrob Chemother. 1989 Apr;23(4):597–604. doi: 10.1093/jac/23.4.597. [DOI] [PubMed] [Google Scholar]
- Couraud L., Fourtillan J. B., Saux M. C., Bryskier A., Vincent du Laurier M. Diffusion of ofloxacin into human lung tissue. Drugs. 1987;34 (Suppl 1):37–38. doi: 10.2165/00003495-198700341-00009. [DOI] [PubMed] [Google Scholar]
- Jacobs F., Marchal M., de Francquen P., Kains J. P., Gangji D., Thys J. P. Penetration of ciprofloxacin into human pleural fluid. Antimicrob Agents Chemother. 1990 May;34(5):934–936. doi: 10.1128/aac.34.5.934. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lam W. K., Chau P. Y., So S. Y., Leung Y. K., Chan J. C., Ip M., Sham M. K. Ofloxacin compared with amoxycillin in treating infective exacerbations in bronchiectasis. Respir Med. 1989 Jul;83(4):299–303. doi: 10.1016/s0954-6111(89)80200-8. [DOI] [PubMed] [Google Scholar]
- Levine H., Metzger W., Lacera D., Kay L. Diagnosis of tuberculous pleurisy by culture of pleural biopsy specimen. Arch Intern Med. 1970 Aug;126(2):269–271. [PubMed] [Google Scholar]
- Monk J. P., Campoli-Richards D. M. Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1987 Apr;33(4):346–391. doi: 10.2165/00003495-198733040-00003. [DOI] [PubMed] [Google Scholar]
- Tsukamura M. In vitro antituberculosis activity of a new antibacterial substance ofloxacin (DL8280). Am Rev Respir Dis. 1985 Mar;131(3):348–351. doi: 10.1164/arrd.1985.131.3.348. [DOI] [PubMed] [Google Scholar]
- Tsukamura M., Nakamura E., Yoshii S., Amano H. Therapeutic effect of a new antibacterial substance ofloxacin (DL8280) on pulmonary tuberculosis. Am Rev Respir Dis. 1985 Mar;131(3):352–356. doi: 10.1164/arrd.1985.131.3.352. [DOI] [PubMed] [Google Scholar]
- Wijnands W. J., Vree T. B., Baars A. M., Hafkenscheid J. C., Kohler B. E., van Herwaarden C. L. The penetration of ofloxacin into lung tissue. J Antimicrob Chemother. 1988 Sep;22 (Suppl 100):85–89. doi: 10.1093/jac/22.supplement_c.85. [DOI] [PubMed] [Google Scholar]
- Yew W. W., Kwan S. Y., Ma W. K., Khin M. A., Chau P. Y. In-vitro activity of ofloxacin against Mycobacterium tuberculosis and its clinical efficacy in multiply resistant pulmonary tuberculosis. J Antimicrob Chemother. 1990 Aug;26(2):227–236. doi: 10.1093/jac/26.2.227. [DOI] [PubMed] [Google Scholar]