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ACP T-cells transferred disease into recipient NOD.scid mice and caused severe insulitis. A: Adoptive transfer of ACP T-cells into NOD.scid recipient mice induced diabetes in 50% (8 of 16) by 22 weeks after transfer. See research design and methods for details. B: Histology of islets from all recipient mice, diabetic and normoglycemic, showed severe, destructive insulitis. The islet histology shown in this figure was taken from a nondiabetic recipient mouse at 30 weeks after transfer.
