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. 1991 Nov;35(11):2444–2446. doi: 10.1128/aac.35.11.2444

Inhibitory effects of recombinant human cystatin C on human coronaviruses.

A R Collins 1, A Grubb 1
PMCID: PMC245403  PMID: 1804023

Abstract

Cystatin C, a potent inhibitor of cysteine proteases such as papain and cathepsin B, was examined for its effect on human coronaviruses OC43 and 229e. Both viruses were greater than 99% inhibited by 0.1 mM inhibitor. Endpoint titrations showed that inhibiting activity paralleled that of leupeptin, a serine and cysteine protease inhibitor, and indicated that 1 to 2 microM inhibitor, slightly above physiologic levels, was effective.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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