Abstract
The activities of six fluoroquinolones were determined for 117 separate strains of Shigella sonnei. The order of increasing activity (MICs for 90% of strains tested) was enoxacin (0.25 micrograms/ml), temafloxacin (0.032 micrograms/ml), sparfloxacin (0.016 micrograms/ml), CI-960 (0.008 micrograms/ml), ciprofloxacin (0.008 micrograms/ml), and PD-131628-2 (0.008 micrograms/ml). These data, along with results of killing and mutational rate studies, showed that all six fluoroquinolones were highly inhibitory against S. sonnei and five fluoroquinolones were rapidly and persistently bactericidal.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barg N. L., Hutson F. S., Wheeler L. A., Thomson C. J., Amyes S. G., Wharton M., Schaffner W. Novel dihydrofolate reductases isolated from epidemic strains of trimethoprim/sulfamethoxazole-resistant Shigella sonnei. J Infect Dis. 1990 Aug;162(2):466–473. doi: 10.1093/infdis/162.2.466. [DOI] [PubMed] [Google Scholar]
- Birnboim H. C., Doly J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 1979 Nov 24;7(6):1513–1523. doi: 10.1093/nar/7.6.1513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Courvalin P. Plasmid-mediated 4-quinolone resistance: a real or apparent absence? Antimicrob Agents Chemother. 1990 May;34(5):681–684. doi: 10.1128/aac.34.5.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Green M. S., Block C., Cohen D., Slater P. E. Four decades of shigellosis in Israel: epidemiology of a growing public health problem. Rev Infect Dis. 1991 Mar-Apr;13(2):248–253. doi: 10.1093/clinids/13.2.248. [DOI] [PubMed] [Google Scholar]
- John J. F., Jr, Twitty J. A. Plasmids as epidemiologic markers in nosocomial gram-negative bacilli: experience at a university and review of the literature. Rev Infect Dis. 1986 Sep-Oct;8(5):693–704. doi: 10.1093/clinids/8.5.693. [DOI] [PubMed] [Google Scholar]
- Keusch G. T. Antimicrobial therapy for enteric infections and typhoid fever: state of the art. Rev Infect Dis. 1988 Jan-Feb;10 (Suppl 1):S199–S205. doi: 10.1093/clinids/10.supplement_1.s199. [DOI] [PubMed] [Google Scholar]
- Kumada T., Neu H. C. In-vitro activity of ofloxacin, a quinolone carboxylic acid compared to other quinolones and other antimicrobial agents. J Antimicrob Chemother. 1985 Nov;16(5):563–574. doi: 10.1093/jac/16.5.563. [DOI] [PubMed] [Google Scholar]
- Lee L. A., Shapiro C. N., Hargrett-Bean N., Tauxe R. V. Hyperendemic shigellosis in the United States: a review of surveillance data for 1967-1988. J Infect Dis. 1991 Nov;164(5):894–900. doi: 10.1093/infdis/164.5.894. [DOI] [PubMed] [Google Scholar]
- Maple P. A., Hamilton-Miller J. M., Brumfitt W. Differing activities of quinolones against ciprofloxacin-susceptible and ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1991 Feb;35(2):345–350. doi: 10.1128/aac.35.2.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murray B. E. Quinolones and the gastrointestinal tract. Eur J Clin Microbiol Infect Dis. 1989 Dec;8(12):1093–1101. doi: 10.1007/BF01975176. [DOI] [PubMed] [Google Scholar]
- Nord C. E. Effect of new quinolones on the human gastrointestinal microflora. Rev Infect Dis. 1988 Jan-Feb;10 (Suppl 1):S193–S196. doi: 10.1093/clinids/10.supplement_1.s193. [DOI] [PubMed] [Google Scholar]
- Segreti J., Nelson J. A., Goodman L. J., Kaplan R. L., Trenholme G. M. In vitro activities of lomefloxacin and temafloxacin against pathogens causing diarrhea. Antimicrob Agents Chemother. 1989 Aug;33(8):1385–1387. doi: 10.1128/aac.33.8.1385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yagupsky P., Loeffelholz M., Bell K., Menegus M. A. Use of multiple markers for investigation of an epidemic of Shigella sonnei infections in Monroe County, New York. J Clin Microbiol. 1991 Dec;29(12):2850–2855. doi: 10.1128/jcm.29.12.2850-2855.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]