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. 1974 Jul;119(1):123–128. doi: 10.1128/jb.119.1.123-128.1974

Effect of Preirradiation Ribonucleic Acid Synthesis Inhibition on Resistance to Ultraviolet Light with Resistant and Sensitive Strains of Escherichia coli B/r

J M Rudé 1, C O Doudney 1
PMCID: PMC245581  PMID: 4600696

Abstract

The ultraviolet resistance of a streptolydigin-susceptible strain of Escherichia coli B/r hcr− increased during preirradiation treatment with streptolydigin (an inhibitor of deoxyribonucleic acid-dependent ribonucleic acid polymerase) for 20 min and then remained constant. During preirradiation treatment with chloramphenicol (an inhibitor of protein synthesis), resistance to ultraviolet light increased for 1 to 2 h, and reached a maximal level significantly above that attained in streptolydigin-containing medium. These results suggest that there are two mechanisms that function in Hcr− cells during chloramphenicol treatment which contribute to the concomitant ultraviolet resistance enhancement. One is ribonucleic acid dependent and is inhibited by streptolydigin. This ribonucleic acid-dependent mechanism appears to be absent in wild-type and RecA E. coli B/r strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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