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Journal of Bacteriology logoLink to Journal of Bacteriology
. 1974 Dec;120(3):1308–1314. doi: 10.1128/jb.120.3.1308-1314.1974

Cryptopleurine Resistance: Genetic Locus for a 40S Ribosomal Component in Saccharomyces cerevisiae

Paul Grant 1, Lucas Sánchez 1, Antonio Jiménez 1
PMCID: PMC245916  PMID: 4612014

Abstract

Mutants resistant to the phenanthrene alkaloids tylophorine, tylocrebrine, and cryptopleurine have been isolated from the yeast Saccharomyces cerevisiae. A single recessive nuclear gene was responsible for resistance. This resistance locus, cry, was closely linked to the mating locus (2.2 centimorgans). The resistance was ribosomal and was due to an altered 40S ribosomal subunit. The mode of action of these drugs has been examined, and they appear to inhibit the translocation phase of protein synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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