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. 1973 Jul;115(1):235–242. doi: 10.1128/jb.115.1.235-242.1973

R-Factor-Mediated Resistance to Tetracycline in Proteus mirabilis

T J Franklin a,1, R Rownd a
PMCID: PMC246235  PMID: 4268690

Abstract

The expression of R-factor-mediated resistance to tetracycline has been compared in Proteus mirabilis and Escherichia coli. Resistance to a range of concentrations of tetracycline was significantly lower in P. mirabilis than in E. coli in both induced and repressed states. Indirect evidence showed that conditions which result in a marked increase in the level of resistance of P. mirabilis harboring the R factor NR1 to chloramphenicol, streptomycin, and spectinomycin due to an amplification in the number of copies of r-determinants per cell do not detectably increase the level of resistance to tetracycline. Tetracycline resistance was inducible in early stationary-phase P. mirabilis NR1 although not after 5 h in this state. Double isotope labeling of control and tetracycline-induced P. mirabilis NR1 in early stationary phase revealed isotopic enrichment of certain peaks in extracts from induced cells subjected to polyacrylamide gel electrophoresis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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