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. 2006 Jun 2;28(2):191–200. doi: 10.1007/s11357-006-9004-x

Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice

Karen T Coschigano 1,✉
PMCID: PMC2464722  PMID: 19943140

Abstract

Since generation of the growth hormone receptor/binding protein (GHR/BP) gene-disrupted mouse nearly 10 years ago, use of this mouse model has become widespread in the elucidation of the physiological roles of GH and insulin-like growth factor-1 (IGF-1). In particular, it serves as a useful model to study mechanisms of aging. This review highlights the evidence demonstrating that the loss of GH signaling leads to lifespan extension in mice, and presents the multiple characteristics of this mouse line that suggest the life extension is due to alteration of the aging process.

Key words: aging, gene disruption, growth hormone receptor/binding protein, longevity, mice

Abbreviations

+/+

wild-type

AMPK

AMP-activated protein kinase

CR

caloric restriction

CREB

cAMP response element-binding protein

Foxo1

forkhead box O1

FSH

follicle stimulating hormone

G6Pase

glucose-6-phosphatase

GHR/BP

growth hormone receptor/ binding protein

GHR/ BP -/-

homozygous for the GHR/BP gene disruption

GLUT4

glucose transporter 4

HI

high isoflavone

IGF-1

insulin-like growth factor-1

IR

insulin receptor

IRS-1

insulin receptor substrate-1

IRS-2

insulin receptor substrate-2

KO

knockout

LH

leutenizing hormone

LI

low isoflavone

MnSOD

manganese superoxide dismutase

MRDT

mortality rate doubling time

PEPCK

phosphoenolpyruvate carboxykinase

PGC-1α

peroxisome proliferator-activated receptor-γ coactivator 1α

PIN

prostatic intraepithelial neoplasia

PPAR

peroxisome proliferator- activated receptor

RXR

retinoid X receptor

T3

triiodothyronine

T4

thyroxine

Tag

large T antigen

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