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. 1973 Dec;116(3):1253–1257. doi: 10.1128/jb.116.3.1253-1257.1973

Stringent Control of Intracellular Proteolysis in Escherichia coli

Martin J Pine 1
PMCID: PMC246481  PMID: 4584808

Abstract

Regulation of intracellular proteolysis has been compared during amino acid deficiencies in seven double auxotrophs of Escherichia coli 9723f with a common phenylalanine requirement. Individual deficiencies were either more effective than, less effective, or equal to phenylalanine deficiency in stimulating intracellular proteolysis. For each amino acid, the same relationship prevailed in inhibiting uracil incorporation into nucleic acids, a reaction series regulated by the rel gene for stringent control. The three amino acids least abundant in the cellular protein were the least effective regulators. These findings are interpreted as supportive evidence for stringent control of intracellular proteolysis by the rel gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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