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. 1968 May;44(511):347–362. doi: 10.1136/pgmj.44.511.347

Biochemistry of hyperthyroidism and hypothyroidism*

Frederic L Hoch
PMCID: PMC2466600  PMID: 4871771

Abstract

The thyroid hormones act directly on mitochondria, and thereby control the transformation of the energy derived from oxidations into a form utilizable by the cell. Through their direct actions on mitochondria, the hormones also control indirectly the rate of protein synthesis and thereby the amount of oxidative apparatus in the cell. A rationale for the effects of thyroid hormone excess or deficiency is based upon studies of the mechanism of thyroid hormone action. In hypothyroidism, slow fuel consumption leads to a low output of utilizable energy. In hyperthyroidism, rapid fuel consumption leads to a high energy output, but as efficiency decreases, the utilizable energy produced decreases. Many of the chemical and physical features of these diseases can be reduced to changes in available energy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BREWSTER W. R., Jr, ISAACS J. P., OSGOOD P. F., KING T. L. The hemodynamic and metabolic interrelationships in the activity of epinephrine, norepinephrine and the thyroid hormones. Circulation. 1956 Jan;13(1):1–20. doi: 10.1161/01.cir.13.1.1. [DOI] [PubMed] [Google Scholar]
  2. BROITMAN S. A., BONDY D. C., YACHNIN I., HOSKINS L. C., INGBAR S., ZAMCHECK N. ABSORPTION AND DISPOSITION OF D-XYLOSE IN THYROTOXICOSIS AND MYXEDEMA. N Engl J Med. 1964 Feb 13;270:333–337. doi: 10.1056/NEJM196402132700703. [DOI] [PubMed] [Google Scholar]
  3. BRONK J. R. THE NATURE OF THE ENERGY REQUIREMENT FOR AMINO ACID INCORPORATION BY ISOLATED MITOCHONDRIA AND ITS SIGNIFICANCE FOR THYROID HORMONE ACTION. Proc Natl Acad Sci U S A. 1963 Sep;50:524–526. doi: 10.1073/pnas.50.3.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BURTON S. D., ROBBINS E. D., BYERS S. O. Utilization of glucose by hyperthyroid isolated rat liver. Proc Soc Exp Biol Med. 1956 Jun;92(2):272–273. doi: 10.3181/00379727-92-22449. [DOI] [PubMed] [Google Scholar]
  5. Bargoni N., Grillo M. A., Rinaudo M. T., Fossa T., Ayassot M. L., Bozzi M. L. Sulla glicolisi e la glicogenesi nel fegato di ratti ipotiroidei. Boll Soc Ital Biol Sper. 1964 Dec 31;40(24 Suppl):1888–1890. [PubMed] [Google Scholar]
  6. Brodie B. B., Davies J. I., Hynie S., Krishna G., Weiss B. Interrelationships of catecholamines with other endocrine systems. Pharmacol Rev. 1966 Mar;18(1):273–289. [PubMed] [Google Scholar]
  7. Bronk J. R. Thyroid hormone: effects on electron transport. Science. 1966 Aug 5;153(3736):638–639. doi: 10.1126/science.153.3736.638. [DOI] [PubMed] [Google Scholar]
  8. Burn J. H., Marks H. P. The relation of the thyroid gland to the action of insulin. J Physiol. 1925 Jul 14;60(3):131–141. doi: 10.1113/jphysiol.1925.sp002230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CHATAGNER F., GAUTHERON D. [Influence of thyroid hormones on the adenosine triphosphate content of the rat liver]. Biochim Biophys Acta. 1960 Jul 15;41:544–545. doi: 10.1016/0006-3002(60)90060-3. [DOI] [PubMed] [Google Scholar]
  10. CHILSON O. P., SACKS J. Effect of hyperthyroidism on distribution of adenosine phosphates and glycogen in liver. Proc Soc Exp Biol Med. 1959 Jun;101(2):331–332. doi: 10.3181/00379727-101-24928. [DOI] [PubMed] [Google Scholar]
  11. COOPER C., TAPLEY D. F. Effect of thyroxine on the swelling of mitochondria isolated from various tissues of the rat. Nature. 1956 Nov 17;178(4542):1119–1119. doi: 10.1038/1781119a0. [DOI] [PubMed] [Google Scholar]
  12. CRISPELL K. R., PARSON W., HOLLIFIELD G. A study of the rate of protein synthesis before and during the administration of L-triiodothyronine to patients with myxedema and healthy volunteers using N-15 glycine. J Clin Invest. 1956 Feb;35(2):164–169. doi: 10.1172/JCI103261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Chance B. Reaction of oxygen with the respiratory chain in cells and tissues. J Gen Physiol. 1965 Sep;49(1 Suppl):163–195. doi: 10.1085/jgp.49.1.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. D'IORIO A., LEDUC J. The influence of thyroxine on the O-methylation of catechols. Arch Biochem Biophys. 1960 Apr;87:224–227. doi: 10.1016/0003-9861(60)90164-8. [DOI] [PubMed] [Google Scholar]
  15. DAYTON S., DAYTON J., DRIMMER F., KENDALL F. E. Rates of acetate turnover and lipid synthesis in normal, hypothyroid and hyperthyroid rats. Am J Physiol. 1960 Jul;199:71–76. doi: 10.1152/ajplegacy.1960.199.1.71. [DOI] [PubMed] [Google Scholar]
  16. DEITRICH R. A., SMITH D. L. Effect of the thyroid on butyrate oxidation in the rat heart. Biochem Pharmacol. 1960 May;3:85–88. doi: 10.1016/0006-2952(60)90024-1. [DOI] [PubMed] [Google Scholar]
  17. DOW D. S., ALLEN C. E. Steady-state oxidation of glucose in hyperthyroid and hypothyroid rats. Can J Biochem Physiol. 1961 Jun;39:981–990. doi: 10.1139/o61-098. [DOI] [PubMed] [Google Scholar]
  18. Dow D. S. The isolation from thyrotoxic and diabetic rats of skeletal muscle mitochondria showing tight coupling, high respiratory indices, and normal adenosine triphosphatase activities. Biochemistry. 1967 Nov;6(11):3350–3355. doi: 10.1021/bi00863a003. [DOI] [PubMed] [Google Scholar]
  19. ELLIS S. The metabolic effects of epinephrine and related amines. Pharmacol Rev. 1956 Dec;8(4):485–565. [PubMed] [Google Scholar]
  20. ELRICK H., HLAD C. J., Jr, ARAI Y. Influence of thyroid function on carbohydrate metabolism and a new method for assessing response to insulin. J Clin Endocrinol Metab. 1961 Apr;21:387–400. doi: 10.1210/jcem-21-4-387. [DOI] [PubMed] [Google Scholar]
  21. ERNSTER L., IKKOS D., LUFT R. Enzymic activities of human skeletal muscle mitochondria: a tool in clinical metabolic research. Nature. 1959 Dec 12;184:1851–1854. doi: 10.1038/1841851a0. [DOI] [PubMed] [Google Scholar]
  22. ERNSTER L., LUFT R. MITOCHONDRIAL RESPIRATORY CONTROL: BIOCHEMICAL, PHYSIOLOGICAL, AND PATHOLOGICAL ASPECTS. Adv Metab Disord. 1964;15:95–123. doi: 10.1016/b978-1-4831-6748-0.50008-2. [DOI] [PubMed] [Google Scholar]
  23. FERRINI O., PERRONI G. L., BESTAGNO M. [Study on the distribution of methionine-S-35 in the rat; hormonal influence on the incorporation of amino acids into muscle proteins]. Minerva Nucl. 1959 Jun;3:210–213. [PubMed] [Google Scholar]
  24. FIRMAT G., PRUNIER J., RAWSON R. W., ROBERTS K. E., SCHWARTZ M. K. Effect of phosphate in enhancing the action of triiodothyronine. Endocrinology. 1956 Nov;59(5):565–570. doi: 10.1210/endo-59-5-565. [DOI] [PubMed] [Google Scholar]
  25. FLETCHER K., MYANT N. B. Effect of thyroxine on the synthesis of lipids in rat liver. Endocrinology. 1962 Dec;71:870–877. doi: 10.1210/endo-71-6-870. [DOI] [PubMed] [Google Scholar]
  26. FLETCHER K., MYANT N. B. Effects of thyroxine on the synthesis of cholesterol and fatty acids by cell-free fractions of rat liver. J Physiol. 1960 Nov;154:145–152. doi: 10.1113/jphysiol.1960.sp006569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Fisher J. N., Ball E. G. Studies on the metabolism of adipose tissue. XX. The effect of thyroid status upon oxygen consumption and lipolysis. Biochemistry. 1967 Mar;6(3):637–647. doi: 10.1021/bi00855a001. [DOI] [PubMed] [Google Scholar]
  28. GANJU S. N., LOCKETT M. F. The action of thyroid hormones on the oxygen consumption and resistance to cold of adrenalectomized and thyroidectomized-adrenalectomized mice. J Endocrinol. 1958 Apr;16(4):396–402. doi: 10.1677/joe.0.0160396. [DOI] [PubMed] [Google Scholar]
  29. GERSHBERG H., KUHL W. J., Jr Acetylation studies in human subjects with metabolic disorders. J Clin Invest. 1950 Dec;29(12):1625–1632. doi: 10.1172/JCI102406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. GERSHOFF S. N., VITALE J. J., ANTONOWICZ I., NAKAMURA M., HELLERSTEIN E. E. Studies of interrelationships of thyroxine, magnesium, and vitamin B12. J Biol Chem. 1958 Apr;231(2):849–854. [PubMed] [Google Scholar]
  31. GLOCK G. E., MCLEAN P., WHITEHEAD J. K. Pathways of glucose catabolism in rat liver in alloxan diabetes and hyperthyroidism. Biochem J. 1956 Jul;63(3):520–524. doi: 10.1042/bj0630520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. GOODMAN H. M., KNOBIL E. Mobilization of fatty acids by epinephrine in normal and hypophysectomized rhesus monkeys. Proc Soc Exp Biol Med. 1959 Jan;100(1):195–197. doi: 10.3181/00379727-100-24570. [DOI] [PubMed] [Google Scholar]
  33. Goodman H. M., Bray G. A. Role of thyroid hormones in lipolysis. Am J Physiol. 1966 May;210(5):1053–1058. doi: 10.1152/ajplegacy.1966.210.5.1053. [DOI] [PubMed] [Google Scholar]
  34. HAGEN J. H. Effect of insulin on the metabolism of adipose tissue from hyperthyroid rats. J Biol Chem. 1960 Sep;235:2600–2603. [PubMed] [Google Scholar]
  35. HARARY I. The effect in vivo of thyroxine on acyl phosphatase of rat liver and muscle. Biochim Biophys Acta. 1958 Sep;29(3):647–648. doi: 10.1016/0006-3002(58)90027-1. [DOI] [PubMed] [Google Scholar]
  36. HED R., KIRSTEIN L., LUNDMARK C. Thyrotoxic myopathy. J Neurol Neurosurg Psychiatry. 1958 Nov;21(4):270–278. doi: 10.1136/jnnp.21.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. HERNBERG C. A. Bone phosphorus metabolism in vitro in thyrotoxicosis. Acta Endocrinol (Copenh) 1960 Apr;33:577–583. doi: 10.1530/acta.0.xxxiii0577. [DOI] [PubMed] [Google Scholar]
  38. HOCH F. L. Biochemical actions of thyroid hormones. Physiol Rev. 1962 Oct;42:605–673. doi: 10.1152/physrev.1962.42.4.605. [DOI] [PubMed] [Google Scholar]
  39. HOCH F. L. SYNERGISM BETWEEN CALORIGENIC EFFECTS: L-THYROXINE AND 2,4-DINITROPHENOL OR SODIUM SALICYLATE IN EUTHYROID RATS. Endocrinology. 1965 Feb;76:335–339. doi: 10.1210/endo-76-2-335. [DOI] [PubMed] [Google Scholar]
  40. HOCH F. L. Thyrotoxicosis as a disease of mitochondria. N Engl J Med. 1962 Mar 8;266:498–concl. doi: 10.1056/NEJM196203082661007. [DOI] [PubMed] [Google Scholar]
  41. Hoch F. L. Early action of injected L-thyroxine on mitochondrial oxidative phosphorylation. Proc Natl Acad Sci U S A. 1967 Aug;58(2):506–512. doi: 10.1073/pnas.58.2.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Hoch F. L. L-thyroxine in subcalorigenic doses: rapid potentiation of dinitrophenol-induced calorigenesis in hypothyroid rats. Endocrinology. 1965 Dec;77(6):991–998. doi: 10.1210/endo-77-6-991. [DOI] [PubMed] [Google Scholar]
  43. Hoch F. L., Lipmann F. THE UNCOUPLING OF RESPIRATION AND PHOSPHORYLATION BY THYROID HORMONES. Proc Natl Acad Sci U S A. 1954 Oct;40(10):909–921. doi: 10.1073/pnas.40.10.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Hoch F. L., Motta M. V. Reversal of early thyroid hormone action on mitochondria by bovine serum albumin in vitro. Proc Natl Acad Sci U S A. 1968 Jan;59(1):118–122. doi: 10.1073/pnas.59.1.118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Hoch F. L. Rapid effects of a subcalorigenic dose of L-thyroxine on mitochondria. J Biol Chem. 1966 Jan 25;241(2):524–525. [PubMed] [Google Scholar]
  46. JEANRENAUD B. Dynamic aspects of adipose tissue metabolism: a review. Metabolism. 1961 Jul;10:535–581. [PubMed] [Google Scholar]
  47. JOHNSON P. C., POSEY A. F., PATRICK D. R., CAPUTTO R. Incorporation of P in the muscle by normal and thyrotoxic resting rats. Am J Physiol. 1958 Feb;192(2):279–282. doi: 10.1152/ajplegacy.1958.192.2.279. [DOI] [PubMed] [Google Scholar]
  48. Jones J. E., Desper P. C., Shane S. R., Flink E. B. Magnesium metabolism in hyperthyroidism and hypothyroidism. J Clin Invest. 1966 Jun;45(6):891–900. doi: 10.1172/JCI105404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. KARP A., STETTEN D., Jr The effect of thyroid activity on certain anabolic processes studied with the aid of deuterium. J Biol Chem. 1949 Jun;179(2):819–830. [PubMed] [Google Scholar]
  50. KASBEKAR D. K., LAVATE W. V., REGE D. V., SREENIVASAN A. A study of vitamin B12 protection in experimental thyrotoxicosis in the rat. Biochem J. 1959 Jul;72:374–383. doi: 10.1042/bj0720374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. KLEBANOFF S. J. An effect of thyroxine and related compounds on the oxidation of certain hydrogen donors by the peroxidase system. J Biol Chem. 1959 Sep;234:2437–2442. [PubMed] [Google Scholar]
  52. KRANE S. M., BROWNELL G. L., STANBURY J. B., CORRIGAN H. The effect of thyroid disease on calcium metabolism in man. J Clin Invest. 1956 Aug;35(8):874–887. doi: 10.1172/JCI103340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. KRITCHEVSKY D. Influence of thyroid hormones and related compounds on cholesterol biosynthesis and degradation: a review. Metabolism. 1960 Nov;9:984–994. [PubMed] [Google Scholar]
  54. LABOUESSE J., CHATAGNER F., JOLLES-BERGERET B. [Determination of pyridoxal phosphate in the liver of the normal rat, the thyrotoxic rat and the thyroidectomized rat]. Biochim Biophys Acta. 1960 Apr 8;39:372–374. doi: 10.1016/0006-3002(60)90182-7. [DOI] [PubMed] [Google Scholar]
  55. LENGEMANN F. W., WASSERMAN R. H., COMAR C. L. The effect of growth and thyroid hormones upon the removal by lavage of calcium and strontium from the skeleton of the rat. Endocrinology. 1960 Oct;67:535–539. doi: 10.1210/endo-67-4-535. [DOI] [PubMed] [Google Scholar]
  56. LESLIE I., SINCLAIR R. The action of thyroxine and triiodothyronine on human cells growing in tissue culture. Exp Cell Res. 1959 May;17(2):272–285. doi: 10.1016/0014-4827(59)90219-8. [DOI] [PubMed] [Google Scholar]
  57. Lamberg B. A. Glucose metabolism in thyroid disease. Acta Med Scand. 1965 Sep;178(3):351–362. doi: 10.1111/j.0954-6820.1965.tb04279.x. [DOI] [PubMed] [Google Scholar]
  58. MACHO L. Effect of thyroxine and 2, 4-dinitrophenol on the rate of utilization of glucose. Nature. 1961 Aug 5;191:604–604. doi: 10.1038/191604a0. [DOI] [PubMed] [Google Scholar]
  59. MACHO L. The influence of endocrine glands on carbohydrate metabolism. II. The glucose tolerance and clearance of glucose in healthy subjects and in patients with hypo- and hyperthyroidism. Acta Med Scand. 1958 May 6;160(6):485–490. [PubMed] [Google Scholar]
  60. MALEY G. F. Comparison of some enzyme systems in normal and thyrotoxic rat livers. Am J Physiol. 1957 Jan;188(1):35–39. doi: 10.1152/ajplegacy.1956.188.1.35. [DOI] [PubMed] [Google Scholar]
  61. MALEY G. F., LARDY H. A. Efficiency of phosphorylation in selected oxidations by mitochondria from normal and thyrotoxic rat livers. J Biol Chem. 1955 Jul;215(1):377–388. [PubMed] [Google Scholar]
  62. MALEY G. F., LARDY H. A. Metabolic effects of thyroid hormones in vitro. II. Influence of thyroxine and triiodothyronine on oxidative phosphorylation. J Biol Chem. 1953 Sep;204(1):435–444. [PubMed] [Google Scholar]
  63. MARTIUS C., HESS B. Uber den Wirkungsmechanismus des Schilddrüsenhormons. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1952;216(1-2):45–48. [PubMed] [Google Scholar]
  64. MIGICOVSKY B. B., SCAIFE J. F. Effect of alloxan, insulin, and thyroxine on cholesterol and fatty acid synthesis by rat liver homogenates. Can J Biochem Physiol. 1957 Jan;35(1):15–23. [PubMed] [Google Scholar]
  65. MILLIKAN C. H., HAINES S. F. The thyroid gland in relation to neuromuscular disease. AMA Arch Intern Med. 1953 Jul;92(1):5–39. doi: 10.1001/archinte.1953.00240190017002. [DOI] [PubMed] [Google Scholar]
  66. MUNRO D. S., RENSCHLER H., WILSON G. M. Exchangeable potassium and sodium in hyperthyroidism and hypothyroidism. Metabolism. 1958 Mar;7(2):124–132. [PubMed] [Google Scholar]
  67. NIKKILA E. A., PITKANEN E. Liver enzyme pattern in thyrotoxicosis; determination of 14 enzymes in samples removed by needle biopsy. Acta Endocrinol (Copenh) 1959 Aug;31:573–586. [PubMed] [Google Scholar]
  68. NISHIKAWARA M. T., GABRIELSON E. Hexokinase and phosphatase activities of the intestinal mucosa in hypophysectomized and thyroid-treated hypophysectomized rats. Endocrinology. 1961 May;68:855–857. doi: 10.1210/endo-68-5-855. [DOI] [PubMed] [Google Scholar]
  69. OKUDA K., CHOW B. F. The thyroid and absorption of vitamin B12 in rats. Endocrinology. 1961 Apr;68:607–615. doi: 10.1210/endo-68-4-607. [DOI] [PubMed] [Google Scholar]
  70. Peter J. B., Lee L. D. Characteristics of skeletal muscle mitochondria isolated by a new, improved technique. Biochem Biophys Res Commun. 1967 Nov 17;29(3):430–436. doi: 10.1016/0006-291x(67)90475-5. [DOI] [PubMed] [Google Scholar]
  71. Peters R. A., Rossiter R. J. Thyroid and vitamin B(1). Biochem J. 1939 Jul;33(7):1140–1150. doi: 10.1042/bj0331140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. RICH C., BIERMAN E. L., SCHWARTZ I. L. Plasma nonesterified fatty acids in hyperthyroid states. J Clin Invest. 1959 Feb;38(2):275–278. doi: 10.1172/JCI103799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. ROODYN D. B., FREEMAN K. B., TATA J. R. THE STIMULATION BY TREATMENT IN VIVO WITH TRI-IODOTHYRONINE OF AMINO ACID INCORPORATION INTO PROTEIN BY ISOLATED RAT-LIVER MITOCHONDRIA. Biochem J. 1965 Mar;94:628–641. doi: 10.1042/bj0940628. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. ROSENMAN R. H., BYERS S. O., FRIEDMAN M. The mechanism responsible for the altered blood cholesterol content in deranged thyroid states. J Clin Endocrinol Metab. 1952 Oct;12(10):1287–1299. doi: 10.1210/jcem-12-10-1287. [DOI] [PubMed] [Google Scholar]
  75. RUPP J., PASCHKIS K. E., CANTAROW A. Influence of thyroxine on protein metabolism. Endocrinology. 1949 May;44(5):449–453. doi: 10.1210/endo-44-5-449. [DOI] [PubMed] [Google Scholar]
  76. Rivlin R. S., Langdon R. G. Regulation of hepatic FAD levels by thyroid hormone. Adv Enzyme Regul. 1966;4:45–58. doi: 10.1016/0065-2571(66)90006-9. [DOI] [PubMed] [Google Scholar]
  77. SELENKOW H. A., MARCUS F. I. Masked hyperthyroidism and heart disease. Med Clin North Am. 1960 Sep;44:1305–1322. doi: 10.1016/s0025-7125(16)33964-5. [DOI] [PubMed] [Google Scholar]
  78. SOKOLOFF L., FRANCIS C. M., CAMPBELL P. L. THYROXINE STIMULATION OF AMINO ACID INCORPORATION INTO PROTEIN INDEPENDENT OF ANY ACTION ON MESSENGER RNA SYNTHESIS. Proc Natl Acad Sci U S A. 1964 Sep;52:728–736. doi: 10.1073/pnas.52.3.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. SOKOLOFF L., KAUFMAN S., CAMPBELL P. L., FRANCIS C. M., GELBOIN H. V. Thyroxine stimulation of amino acid incorporation into protein. Localization of stimulated step. J Biol Chem. 1963 Apr;238:1432–1437. [PubMed] [Google Scholar]
  80. SOKOLOFF L., KAUFMAN S. Effects of thyroxin on amino acid incorporation into protein. Science. 1959 Feb 27;129(3348):569–570. doi: 10.1126/science.129.3348.569. [DOI] [PubMed] [Google Scholar]
  81. SOKOLOFF L., KAUFMAN S. Thyroxine stimulation of amino acid incorporation into protein. J Biol Chem. 1961 Mar;236:795–803. [PubMed] [Google Scholar]
  82. TABACHNICK I. I., BONNYCASTLE D. D. The effect of thyroxine on the coenzyme A content of some tissues. J Biol Chem. 1954 Apr;207(2):757–760. [PubMed] [Google Scholar]
  83. TAPLEY D. F. Magnesium balance in myxedematous patients treated with triiodothyronine: preliminary note. Bull Johns Hopkins Hosp. 1955 Jun;96(6):274–278. [PubMed] [Google Scholar]
  84. TATA J. R., ERNSTER L., LINDBERG O., ARRHENIUS E., PEDERSEN S., HEDMAN R. The action of thyroid hormones at the cell level. Biochem J. 1963 Mar;86:408–428. doi: 10.1042/bj0860408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. TATA J. R. Inhibition of the biological action of thyroid hormones by actinomycin D and puromycin. Nature. 1963 Mar 23;197:1167–1168. doi: 10.1038/1971167a0. [DOI] [PubMed] [Google Scholar]
  86. Tata J. R. The formation and distribution of ribosomes during hormone-induced growth and development. Biochem J. 1967 Jul;104(1):1–16. doi: 10.1042/bj1040001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Tata J. R., Widnell C. C. Ribonucleic acid synthesis during the early action of thyroid hormones. Biochem J. 1966 Feb;98(2):604–620. doi: 10.1042/bj0980604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. WAINFAN E., MARX W. Effects of thyroxine and some related compounds on bacterial oxidations. J Biol Chem. 1955 May;214(1):441–445. [PubMed] [Google Scholar]
  89. WEISS W. P., SOKOLOFF L. Reversal of thyroxine-induced hypermetabolism by puromycin. Science. 1963 Jun 21;140(3573):1324–1326. doi: 10.1126/science.140.3573.1324. [DOI] [PubMed] [Google Scholar]
  90. WERTHEIMER E., BENTOR V. Metabolic changes in the rat diaphragm during heat regulation, as a thyroxine effect. Metabolism. 1953 Nov;2(6):536–545. [PubMed] [Google Scholar]
  91. WHITE J. E., ENGEL F. L. Lipolytic action of corticotropin on rat adipose tissue in vitro. J Clin Invest. 1958 Nov;37(11):1556–1563. doi: 10.1172/JCI103748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. WIDNELL C. C., TATA J. R. Stimulation of nuclear RNA polymerase during the latent period of action of thyroid hormones. Biochim Biophys Acta. 1963 Jul 30;72:506–508. [PubMed] [Google Scholar]
  93. WISWELL J. G. Some effects of magnesium loading in patients with thyroid disorders. J Clin Endocrinol Metab. 1961 Jan;21:31–38. doi: 10.1210/jcem-21-1-31. [DOI] [PubMed] [Google Scholar]
  94. WOHL M. G., LEVY H. A., SZUTKA A., MALDIA G. Pyridoxine deficiency in hyperthyroidism. Proc Soc Exp Biol Med. 1960 Dec;105:523–527. doi: 10.3181/00379727-105-26164. [DOI] [PubMed] [Google Scholar]
  95. Wilkins L., Fleischmann W. EFFECTS OF THYROID ON CREATINE METABOLISM WITH A DISCUSSION OF THE MECHANISM OF STORAGE AND EXCRETION OF CREATINE BODIES. J Clin Invest. 1946 May;25(3):360–377. doi: 10.1172/JCI101717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. ZILE M., LARDY H. A. Monoamine oxidase activity in liver of thyroid-fed rats. Arch Biochem Biophys. 1959 Jun;82(2):411–421. doi: 10.1016/0003-9861(59)90137-7. [DOI] [PubMed] [Google Scholar]

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