Abstract
Six hundred and thirteen male patients with acute uncomplicated gonorrhoea have been treated alternately with single injections of 1·2 mega-units of aqueous procaine penicillin alone or with the same dose and preparation of penicillin with an additional 1·0 g of probenecid given orally immediately prior to injection.
Whether the failure rates were assessed on the basis of an absence of further sexual exposure or by classifying all recurrences within 1 or 2 weeks regardless of history as treatment failures the results were significantly better when probenecid was also given.
The use of a single dose of probenecid is thus capable of maintaining the success of single injection procedures for the treatment of gonorrhoea based on procaine penicillin and thus represents a bulwark for the future should the powers of penicillin against the gonococcus in London deteriorate further.
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Selected References
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- CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HILTON A. L. Treatment of gonorrhoea with P.A.M. and probenecid. Br J Vener Dis. 1959 Dec;35:249–251. doi: 10.1136/sti.35.4.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmes K. K., Johnson D. W., Floyd T. M. Studies of venereal disease. I. Probenecid-procaine penicillin G combination and tetracycline hydrochloride in the treatment of "penicillin-resistant" gonorrhea in men. JAMA. 1967 Nov 6;202(6):461–473. doi: 10.1001/jama.202.6.461. [DOI] [PubMed] [Google Scholar]
- JENSEN P. E., KVORNING S. A., NORREDAM K. PROBENECID AS AN ADJUVANT IN THE TREATMENT OF GONORRHOEA WITH PENICILLIN. Br J Vener Dis. 1963 Dec;39:238–240. doi: 10.1136/sti.39.4.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LETCHNER E. H., NICOL C. S. A comparison of sensitivity to pencillin of N. gonorrhoeae, 1960 and 1958. Br J Vener Dis. 1961 Jun;37:158–160. doi: 10.1136/sti.37.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leigh D. A., Le Franc J., Turnbull A. R. Sensitivity to penicillin of Neisseria gonorrhoeae. Relationship to the results of treatment. Br J Vener Dis. 1969 Jun;45(2):151–153. doi: 10.1136/sti.45.2.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lomholt G., Berg O. Gonorrhoea situation in South Greenland in the summer of 1964. Br J Vener Dis. 1966 Mar;42(1):1–7. doi: 10.1136/sti.42.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morrison G. D., Cobbold R. J., Bor S., Spitzer R. J., Foster D. N., Willcox R. R. Treatment of gonococcal urethritis with single injections of 2-4 mega units of aqueous procaine penicillin. Br J Vener Dis. 1968 Dec;44(4):319–323. doi: 10.1136/sti.44.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morton R. S. Epidemiology of Gonorrhoea: A DEPARTURE FROM THE TYPICAL INCIDENCE PICTURE. Br J Vener Dis. 1963 Jun;39(2):105–108. doi: 10.1136/sti.39.2.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nicol C. S., Ridley M., Symonds M. A. The problem of penicillin resistant gonococci. Br J Vener Dis. 1968 Dec;44(4):315–318. doi: 10.1136/sti.44.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Odegaard K., Gjessing H. C. Is gonococcal sensitivity to antibiotics increasing in Norway? Br J Vener Dis. 1967 Dec;43(4):284–286. doi: 10.1136/sti.43.4.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olsen G. A., Lomholt G. Gonorrhoea treated by a combination of probenecid and sodium penicillin G. Br J Vener Dis. 1969 Jun;45(2):144–148. doi: 10.1136/sti.45.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wren B. G. Gonorrhoea among prostitutes. Med J Aust. 1967 Apr 29;1(17):847–849. doi: 10.5694/j.1326-5377.1967.tb21682.x. [DOI] [PubMed] [Google Scholar]