Abstract
A double glucagon test was performed in 100 patients and seventeen control subjects. Two intravenous doses of glucagon (1 mg) were administered at a 1-hr interval. Glucose was determined before the first injection and 20, 25 and 30 min after both doses, and the increases after each successive dose were added up.
In normal persons, the total increase in glycaemia was higher in the second than in the first hour and reached at least 110 mg. Normal values were found in cases of obstructive jaundice, cholelithiasis and adult diabetes, and abnormal values in patients with infective hepatitis, liver congestion and cirrhosis.
The double glucagon test was found to be very useful for the differential diagnosis of liver cell impairment and hepatic obstruction.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Altschuld R. A., Kruger F. A. Inhibition of hepatic gluconeogenesis in guinea pig by phenformin. Ann N Y Acad Sci. 1968 Mar 26;148(3):612–622. doi: 10.1111/j.1749-6632.1968.tb27735.x. [DOI] [PubMed] [Google Scholar]
- Exton J. H., Jefferson L. S., Jr, Butcher R. W., Park C. R. Gluconeogenesis in the perfused liver. The effects of fasting, alloxan diabetes, glucagon, epinephrine, adenosine 3',5'-monophosphate and insulin. Am J Med. 1966 May;40(5):709–715. doi: 10.1016/0002-9343(66)90151-3. [DOI] [PubMed] [Google Scholar]
- GHANEM M. H., SAID M., HABBIB M., EL-GHALID A., BUTTERFIELD W. J. Glucagon infusion test in bilharzial hepatic fibrosis. Guys Hosp Rep. 1962;111:321–328. [PubMed] [Google Scholar]
- LINKE A. [On the glucagon test in liver diseases and in diabetes mellitus]. Klin Wochenschr. 1959 Aug 15;37:876–877. doi: 10.1007/BF01479903. [DOI] [PubMed] [Google Scholar]
- SUTHERLAND E. W., CORI C. F. Effect of hyperglycemic-glycogenolytic factor and epinephrine on liver phosphorylase. J Biol Chem. 1951 Feb;188(2):531–543. [PubMed] [Google Scholar]
- VAN ITALLIE T. B., BENTLEY W. B. Glucagon-induced hyperglycemia as in index of liver function. J Clin Invest. 1955 Dec;34(12):1730–1737. doi: 10.1172/JCI103227. [DOI] [PMC free article] [PubMed] [Google Scholar]