Abstract
Two hundred and twenty-seven cases of moderate to severe hypertension were treated with thiazide diuretics alone for periods of up to 12 years. In 80% the hypertension was adequately controlled without additional antihypertensive agents.
Hypokalaemic alkalosis was common despite potassium supplements—but caused no symptoms. The incidence of diabetes and gout was low.
It is concluded that thiazide diuretics provide excellent control of hypertension with very few side effects.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Breckenridge A. Hypertension and hyperuricaemia. Lancet. 1966 Jan 1;1(7427):15–18. doi: 10.1016/s0140-6736(66)90005-5. [DOI] [PubMed] [Google Scholar]
- CRANSTON W. I., JUEL-JENSEN B. E., SEMMENCE A. M., JONES R. P., FORBES J. A., MUTCH L. M. EFFECTS OF ORAL DIURETICS ON RAISED ARTERIAL PRESSURE. Lancet. 1963 Nov 9;2(7315):966–970. doi: 10.1016/s0140-6736(63)90671-8. [DOI] [PubMed] [Google Scholar]
- DOLLERY C. T., PENTECOST B. L., SAMAAN N. A. Drug-induced diabetes. Lancet. 1962 Oct 13;2(7259):735–737. doi: 10.1016/s0140-6736(62)90567-6. [DOI] [PubMed] [Google Scholar]
- Hamilton M. Some aspects of the long-term treatment of severe hypertension with methyldopa. Postgrad Med J. 1968 Jan;44(507):66–69. doi: 10.1136/pgmj.44.507.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Healy J. J., McKenna T. J., Canning B. S., Brien T. G., Duffy G. J., Muldowney F. P. Body composition changes in hypertensive subjects on long-term oral diuretic therapy. Br Med J. 1970 Mar 21;1(5698):716–719. doi: 10.1136/bmj.1.5698.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maronde R. F., Milgrom M., Dickey J. M. Potassium loss with thiazide therapy. Am Heart J. 1969 Jul;78(1):16–21. doi: 10.1016/0002-8703(69)90252-x. [DOI] [PubMed] [Google Scholar]
