Abstract
The advantages of intermittent chemotherapy for pulmonary tuberculosis are discussed and the results of several controlled trials summarized. Once-weekly therapy now appears a definite prospect.
The most appropriate approach to therapy at both national and individual physician level now seems to be a combination of unsupervised daily and supervised intermittent regimens.
Full text
PDF







Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CANETTI G., GRUMBACH F., GROSSET J. Long-term, two-stage chemotherapy of advanced experimental murine tuberculosis with intermittent regimes during the second stage. Tubercle. 1963 Jun;44:236–240. doi: 10.1016/s0041-3879(63)80118-x. [DOI] [PubMed] [Google Scholar]
- Corper H. J., Cohn M. L. The Remote Sustained Threshold Therapeutic Action of Streptomycin in Tuberculosis. Science. 1947 Nov 7;106(2758):446–447. doi: 10.1126/science.106.2758.446. [DOI] [PubMed] [Google Scholar]
- Devadatta S., Menon N. K., Nazareth O., Radhakrishna S., Ramakrishnan C. V., Somasundaram P. R., Usha S. P., Velu S. A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis. Tubercle. 1970 Sep;51(3):263–269. doi: 10.1016/0041-3879(70)90018-8. [DOI] [PubMed] [Google Scholar]
- Dickinson J. M., Ellard G. A., Mitchison D. A. Suitability of isoniazid and ethambutol for intermittent administration in the treatment of tuberculosis. Tubercle. 1968 Dec;49(4):351–366. doi: 10.1016/s0041-3879(68)80016-9. [DOI] [PubMed] [Google Scholar]
- FEREBEE S. H., HOPWOOD L., PALMER C. E. Studies on prevention of experimental tuberculosis with isoniazid. II. Effects of different dosage regimens. Am Rev Tuberc. 1956 Dec;74(6):917–939. doi: 10.1164/artpd.1956.74.6.917. [DOI] [PubMed] [Google Scholar]
- Fox W., Robinson D. K., Tall R., Kent P. W., Macfadyen D. M. A study of acute intolerance to ethionamide, including a comparison with prothionamide, and of the influence of a vitamin B-complex additive in prophylaxis. Tubercle. 1969 Jun;50(2):125–143. [PubMed] [Google Scholar]
- Fox W. The John Barnwell Lecture. Changing concepts in the chemotherapy of pulmonary tuberculosis. Am Rev Respir Dis. 1968 May;97(5):767–790. doi: 10.1164/arrd.1968.97.5.767. [DOI] [PubMed] [Google Scholar]
- GANGADHARAM P. R., DEVADATTA S., FOX W., NAIR C. N., SELKON J. B. Rate of inactivation of isoniazid in South Indian patients with pulmonary tuberculosis. 3. Serum concentrations of isoniazid produced by three regimens of isoniazid alone and one of isoniazid plus PAS. Bull World Health Organ. 1961;25:793–806. [PMC free article] [PubMed] [Google Scholar]
- GRUMBACH F., CANETTI G., GROSSET J. FURTHER EXPERIMENTS ON LONG-TERM CHEMOTHERAPY OF ADVANCED MURINE TUBERCULOSIS, WITH EMPHASIS ON INTERMITTENT REGIMES. Tubercle. 1964 Jun;45:125–135. doi: 10.1016/s0041-3879(64)80070-2. [DOI] [PubMed] [Google Scholar]
- GRUMBACH F., RIST N., RIEBEL J. Traitement discontinu de la tuberculose expérimentale de la souris par l'hydrazide isonicotinique (isoniazide). Ann Inst Pasteur (Paris) 1952 Sep;83(3):397–399. [PubMed] [Google Scholar]
- GRUMBACH F. Treatment of experimental murine tuberculosis with different combinations of isoniazid/streptomycin followed by isoniazid alone. Am Rev Respir Dis. 1962 Aug;86:211–215. doi: 10.1164/arrd.1962.86.2.211. [DOI] [PubMed] [Google Scholar]
- Grumbach F., Canetti G., Grosset J., le Lirzin M. Late results of long-term intermittent chemotherapy of advanced, murine tuberculosis: limits of the murine model. Tubercle. 1967 Mar;48(1):11–26. doi: 10.1016/s0041-3879(67)80047-3. [DOI] [PubMed] [Google Scholar]
- Grumbach F., Canetti G., Le Lirzin M. Rifampicin in daily and intermittent treatment of experimental murine tuberculosis, with emphasis on late results. Tubercle. 1969 Sep;50(3):280–293. [PubMed] [Google Scholar]
- HOBBY G. L., LENERT T. F. The control of experimental mouse tuberculosis by the intermittent administration of streptomycin, viomycin, isoniazid, and streptomycylidene isonicotinyl hydrazine. Am Rev Tuberc. 1953 Aug;68(2):292–294. doi: 10.1164/art.1953.68.2.292. [DOI] [PubMed] [Google Scholar]
- HUTTON P. W., LUTALO Y. K., WILLIAMS A. W., TONKIN I. M., FOX W. Acute pulmonary tuberculosis in East Africans: a controlled trial of isoniazid in combination with streptomycin or PAS. Tubercle. 1956 Jun;37(3):151–165. doi: 10.1016/s0041-3879(56)80035-4. [DOI] [PubMed] [Google Scholar]
- MOUNT F. W., FEREBEE S. H. Control study of comparative efficacy of isoniazid, streptomycin-isoniazid, and streptomycin-para-aminosalicylic acid in pulmonary tuberculosis therapy. III. Report on twenty-eight-week observations on 649 patients with streptomycin-susceptible infections. Am Rev Tuberc. 1953 Apr;67(4):539–543. doi: 10.1164/art.1953.67.4.539. [DOI] [PubMed] [Google Scholar]
