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. 1974 Jun;118(3):905–910. doi: 10.1128/jb.118.3.905-910.1974

Regulation of One-Carbon Biosynthesis and Utilization in Escherichia coli

Thomas H Meedel 1, Lewis I Pizer 1
PMCID: PMC246838  PMID: 4598009

Abstract

The regulation of several enzymes involved in one-carbon metabolism was studied in a mutant of Escherichia coli K-12 defective in S-adenosylmethionine synthetase. The mutant that was reported to have a low endogenous concentration of S-adenosylmethionine had elevated levels of N-5, 10-methylene tetrahydrofolate reductase and serine transhydroxymethylase, but the level of N-5, 10-methylene tetrahydrofolate dehydrogenase was not altered. These results suggest that S-adenosylmethionine plays a role in the regulation of one-carbon production and utilization. An enzyme system that cleaved glycine to one-carbon units was demonstrated. The enzymes responsible for the cleavage of glycine were induced by exogenous glycine but were independent of S-adenosylmethionine or purine levels in the cell.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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