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. 1971 Oct;108(1):159–165. doi: 10.1128/jb.108.1.159-165.1971

β-Lactamases of R Factors Derived from Shigella and Salmonella Strains

Philip G Jenkins 1, William T Drabble 1
PMCID: PMC247045  PMID: 5209529

Abstract

R. factors conferring resistance to penicillins and cephalosporins were transferred by conjugation from six strains of Shigella and from four strains of Salmonella typhimurium to a standard strain of S. typhimurium LT2. The β-lactamases produced were then characterized by using cell-free extracts. The enzymes were of two types, I and II, with respect to specific activity against benzyl penicillin, substrate profile, Km, pH optimum, temperature optimum, inhibition by chloride and nitrate ions, and heat inactivation. The six type I enzymes were associated with R factors from Shigella strains; five of these were R(f) factors. The four type II enzymes were associated with R factors from S. typhimurium; all these were R(i) factors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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