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. 1971 Nov;108(2):645–651. doi: 10.1128/jb.108.2.645-651.1971

Mapping the Gene Determining Ornithine Transcarbamylase and Its Operator in Escherichia coli B

George A Jacoby 1
PMCID: PMC247122  PMID: 4942757

Abstract

The gene determining ornithine transcarbamylase in Escherichia coli B is argI, not argF. The argI gene has been located at 84 min on the linkage map, close to the gene for aspartate transcarbamylase, with neighboring markers in clockwise order fdp pyrB argI valS. A mutation in its operator locus, argOI, has been mapped between argI and valS, so that this gene, unlike the argCBH portion of the argECBH cluster, appears to be oriented in the same direction as most of the other known E. coli operons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYER H. GENETIC CONTROL OF RESTRICTION AND MODIFICATION IN ESCHERICHIA COLI. J Bacteriol. 1964 Dec;88:1652–1660. doi: 10.1128/jb.88.6.1652-1660.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beckwith J. R., Signer E. R. Transposition of the lac region of Escherichia coli. I. Inversion of the lac operon and transduction of lac by phi80. J Mol Biol. 1966 Aug;19(2):254–265. doi: 10.1016/s0022-2836(66)80003-7. [DOI] [PubMed] [Google Scholar]
  3. Breckenridge L., Gorini L. Genetic analysis of streptomycin resistance in Escherichia coli. Genetics. 1970 May;65(1):9–25. doi: 10.1093/genetics/65.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cunin R., Elseviers D., Sand G., Freundlich G., Glandsdorff N. On the functional organization of the arg ECBH cluster of genes in Escherichia coli K-12. Mol Gen Genet. 1969;106(1):32–47. doi: 10.1007/BF00332819. [DOI] [PubMed] [Google Scholar]
  5. DAVIS B. D., MINGIOLI E. S. Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950 Jul;60(1):17–28. doi: 10.1128/jb.60.1.17-28.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fraenkel D. G. Genetic mapping of mutations affecting phosphoglucose isomerase and fructose diphosphatase in Escherichia coli. J Bacteriol. 1967 May;93(5):1582–1587. doi: 10.1128/jb.93.5.1582-1587.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GERHART J. C., PARDEE A. B. The enzymology of control by feedback inhibition. J Biol Chem. 1962 Mar;237:891–896. [PubMed] [Google Scholar]
  8. GORINI L., GUNDERSEN W., BURGER M. Genetics of regulation of enzyme synthesis in the arginine biosynthetic pathway of Escherichia coli. Cold Spring Harb Symp Quant Biol. 1961;26:173–182. doi: 10.1101/sqb.1961.026.01.022. [DOI] [PubMed] [Google Scholar]
  9. GORINI L., KALMAN S. M. Control by uracil of carbamyl phosphate synthesis in Escherichia coli. Biochim Biophys Acta. 1963 Feb 5;69:355–360. doi: 10.1016/0006-3002(63)91268-x. [DOI] [PubMed] [Google Scholar]
  10. GORINI L., KATAJA E. PHENOTYPIC REPAIR BY STREPTOMYCIN OF DEFECTIVE GENOTYPES IN E. COLI. Proc Natl Acad Sci U S A. 1964 Mar;51:487–493. doi: 10.1073/pnas.51.3.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GORINI L., KAUFMAN H. Selecting bacterial mutants by the penicillin method. Science. 1960 Feb 26;131(3400):604–605. doi: 10.1126/science.131.3400.604. [DOI] [PubMed] [Google Scholar]
  12. GORINI L. Regulation en retour (feedback control) de la synthèse de l'arginine chez Escherichia coli. Bull Soc Chim Biol (Paris) 1958;40(12):1939–1952. [PubMed] [Google Scholar]
  13. Glansdorff N., Sand G., Verhoef C. The dual genetic control of ornithine transcarbamylase synthesis in Escherichia coli K12. Mutat Res. 1967 Nov-Dec;4(6):743–751. doi: 10.1016/0027-5107(67)90083-8. [DOI] [PubMed] [Google Scholar]
  14. Gottesman S., Beckwith J. R. Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene. J Mol Biol. 1969 Aug 28;44(1):117–127. doi: 10.1016/0022-2836(69)90408-2. [DOI] [PubMed] [Google Scholar]
  15. Hill C. W., Foulds J., Soll L., Berg P. Instability of a missense suppressor resulting from a duplication of genetic material. J Mol Biol. 1969 Feb 14;39(3):563–581. doi: 10.1016/0022-2836(69)90146-6. [DOI] [PubMed] [Google Scholar]
  16. Jacoby G. A., Gorini L. A unitary account of the repression mechanism of arginine biosynthesis in Escherichia coli. I. The genetic evidence. J Mol Biol. 1969 Jan 14;39(1):73–87. doi: 10.1016/0022-2836(69)90334-9. [DOI] [PubMed] [Google Scholar]
  17. LENNOX E. S. Transduction of linked genetic characters of the host by bacteriophage P1. Virology. 1955 Jul;1(2):190–206. doi: 10.1016/0042-6822(55)90016-7. [DOI] [PubMed] [Google Scholar]
  18. LOW B., WOOD T. H. A QUICK AND EFFICIENT METHOD FOR INTERRUPTION OF BACTERIAL CONJUGATION. Genet Res. 1965 Jul;6:300–303. doi: 10.1017/s001667230000416x. [DOI] [PubMed] [Google Scholar]
  19. MAAS R., MAAS W. K. Introduction of a gene from Escherichia coli B into HFR and F-strains of Escherichia coli K-12. Proc Natl Acad Sci U S A. 1962 Nov 15;48:1887–1893. doi: 10.1073/pnas.48.11.1887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MAAS W. K. STUDIES ON THE MECHANISM OF REPRESSION OF ARGININE BIOSYNTHESIS IN ESCHERICHIA COLI. II. DOMINANCE OF REPRESSIBILITY IN DIPLOIDS. J Mol Biol. 1964 Mar;8:365–370. doi: 10.1016/s0022-2836(64)80200-x. [DOI] [PubMed] [Google Scholar]
  21. MAAS W. K. Studies on repression of arginine biosynthesis in Escherichia coli. Cold Spring Harb Symp Quant Biol. 1961;26:183–191. doi: 10.1101/sqb.1961.026.01.023. [DOI] [PubMed] [Google Scholar]
  22. Masters M., Pardee A. B. Sequence of enzyme synthesis and gene replication during the cell cycle of Bacillus subtilis. Proc Natl Acad Sci U S A. 1965 Jul;54(1):64–70. doi: 10.1073/pnas.54.1.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. NOVICK R. P., MAAS W. K. Control by endogenously synthesized arginine of the formation of ornithine transcarbamylase in Escherichia coli. J Bacteriol. 1961 Feb;81:236–240. doi: 10.1128/jb.81.2.236-240.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Prozesky O. W. Transductional analysis of arginineless mutants in Proteus mirabilis. J Gen Microbiol. 1968 Nov;54(1):127–143. doi: 10.1099/00221287-54-1-127. [DOI] [PubMed] [Google Scholar]
  25. Russell R. L., Abelson J. N., Landy A., Gefter M. L., Brenner S., Smith J. D. Duplicate genes for tyrosine transfer RNA in Escherichia coli. J Mol Biol. 1970 Jan 14;47(1):1–13. doi: 10.1016/0022-2836(70)90397-9. [DOI] [PubMed] [Google Scholar]
  26. Taylor A. L. Current linkage map of Escherichia coli. Bacteriol Rev. 1970 Jun;34(2):155–175. doi: 10.1128/br.34.2.155-175.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Taylor A. L., Trotter C. D. Revised linkage map of Escherichia coli. Bacteriol Rev. 1967 Dec;31(4):332–353. doi: 10.1128/br.31.4.332-353.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Tingle M. A., Neidhardt F. C. Mapping of a structural gene for valyl-transfer ribonucleic acid synthetase in Escherichia coli by transduction. J Bacteriol. 1969 May;98(2):837–839. doi: 10.1128/jb.98.2.837-839.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]

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