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. 1972 Jan;109(1):8–11. doi: 10.1128/jb.109.1.8-11.1972

Regulation of the Methionine Feedback-Sensitive Enzyme in Mutants of Salmonella typhimurium

David A Lawrence 1
PMCID: PMC247244  PMID: 4550678

Abstract

Assay of the first enzyme unique to methionine biosynthesis, homoserine-O-transsuccinylase, in metJ and metK regulatory mutants of Salmonella typhimurium showed that synthesis of the enzyme was derepressed seven- and fourfold, respectively. The possibility of noncoordinate regulation of the methionine enzymes is discussed. In metA feedback-resistant mutants, the enzyme activity can be inhibited in vitro by 10 mmS-adenosylmethionine but not by 10 mm l-methionine; hence, the synergistic inhibition found for the wild-type enzyme is not effective in these latter mutants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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