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. 1972 Apr;110(1):47–55. doi: 10.1128/jb.110.1.47-55.1972

Mutagen Stability of Alkylation-Sensitive Mutants of Bacillus subtilis

T Hill a, L Prakash a,1, B Strauss a
PMCID: PMC247377  PMID: 4622905

Abstract

A series of mutations of Bacillus subtilis, conferring sensitivity to methyl methanesulfonate (MMS), were transferred by transformation to a suppressible his− stock. The introduction of certain sensitivity mutations prevented the ultraviolet- or MMS-induced, but not the spontaneous, reversion of his− to his+. Not all sensitivity mutations led to this resistance to mutagenesis; a strain with altered deoxyribonucleic acid (DNA) polymerase activity behaved almost normally with respect to its mutagen response, as did an excision-defective, ultraviolet-sensitive strain used as a control. One of the mutagen-stable strains responded to mutagenesis with nitrosomethylguanidine; another appeared stable even to this mutagen. All mutagen-stable strains had DNA polymerase and DNA ligase activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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