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. 1972 Jun;110(3):809–817. doi: 10.1128/jb.110.3.809-817.1972

Genetic Evidence for the Action of Oxathiin and Thiazole Derivatives on the Succinic Dehydrogenase System of Ustilago maydis Mitochondria

S G Georgopoulos 1, E Alexandri 1, M Chrysayi 1
PMCID: PMC247497  PMID: 5030620

Abstract

The inhibitory effect of fungitoxic derivatives of 1,4-oxathiin on substrate oxidation by the basidiomycete Ustilago maydis is diminished by a single-gene mutation (oxr). The difference between mutant and wild type is approximately the same on the basis of inhibition of either growth and operation of the tricarboxylic acid cycle in intact cells or succinate-driven reduction of ferricyanide by mitochondrial preparations. The mutation affects the behavior of the succinic dehydrogenase system of mitochondria not only in the presence but also in the absence of the toxicant, from which it is concluded that some component of the system itself has been modified. The malonate and the antimycin A sensitivity of the oxr mutant is similar to that of the wild type but cross-resistance to thiazole derivatives is easily demonstrated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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