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. 2005 Sep;74(2):82–92.

Age-related macular degeneration.

V McConnell 1, G Silvestri 1
PMCID: PMC2475376  PMID: 16235759

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abecasis Gonçalo R., Yashar Beverly M., Zhao Yu, Ghiasvand Noor M., Zareparsi Sepideh, Branham Kari E. H., Reddick Adam C., Trager Edward H., Yoshida Shigeo, Bahling John. Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease. Am J Hum Genet. 2004 Feb 16;74(3):482–494. doi: 10.1086/382786. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Age-Related Eye Disease Study Research Group Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: Age-Related Eye Disease Study Report Number 3. Ophthalmology. 2000 Dec;107(12):2224–2232. doi: 10.1016/s0161-6420(00)00409-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Allikmets R. Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am J Hum Genet. 2000 Jul 3;67(2):487–491. doi: 10.1086/303018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ambati Jayakrishna, Ambati Balamurali K., Yoo Sonia H., Ianchulev Sean, Adamis Anthony P. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol. 2003 May-Jun;48(3):257–293. doi: 10.1016/s0039-6257(03)00030-4. [DOI] [PubMed] [Google Scholar]
  5. Anderson Don H., Mullins Robert F., Hageman Gregory S., Johnson Lincoln V. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol. 2002 Sep;134(3):411–431. doi: 10.1016/s0002-9394(02)01624-0. [DOI] [PubMed] [Google Scholar]
  6. Armbrecht Ana Maria, Findlay Catherine, Aspinall Peter Alan, Hill Adrian Robert, Dhillon Baljean. Cataract surgery in patients with age-related macular degeneration: one-year outcomes. J Cataract Refract Surg. 2003 Apr;29(4):686–693. doi: 10.1016/s0886-3350(02)01650-4. [DOI] [PubMed] [Google Scholar]
  7. Beatty S., Koh H., Phil M., Henson D., Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000 Sep-Oct;45(2):115–134. doi: 10.1016/s0039-6257(00)00140-5. [DOI] [PubMed] [Google Scholar]
  8. Bird A. C., Bressler N. M., Bressler S. B., Chisholm I. H., Coscas G., Davis M. D., de Jong P. T., Klaver C. C., Klein B. E., Klein R. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995 Mar-Apr;39(5):367–374. doi: 10.1016/s0039-6257(05)80092-x. [DOI] [PubMed] [Google Scholar]
  9. Bressler N. M., Munoz B., Maguire M. G., Vitale S. E., Schein O. D., Taylor H. R., West S. K. Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Waterman study. Arch Ophthalmol. 1995 Mar;113(3):301–308. doi: 10.1001/archopht.1995.01100030055022. [DOI] [PubMed] [Google Scholar]
  10. Brody B. L., Gamst A. C., Williams R. A., Smith A. R., Lau P. W., Dolnak D., Rapaport M. H., Kaplan R. M., Brown S. I. Depression, visual acuity, comorbidity, and disability associated with age-related macular degeneration. Ophthalmology. 2001 Oct;108(10):1893–1901. doi: 10.1016/s0161-6420(01)00754-0. [DOI] [PubMed] [Google Scholar]
  11. Cho E., Hankinson S. E., Willett W. C., Stampfer M. J., Spiegelman D., Speizer F. E., Rimm E. B., Seddon J. M. Prospective study of alcohol consumption and the risk of age-related macular degeneration. Arch Ophthalmol. 2000 May;118(5):681–688. doi: 10.1001/archopht.118.5.681. [DOI] [PubMed] [Google Scholar]
  12. Christen W. G., Glynn R. J., Manson J. E., Ajani U. A., Buring J. E. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA. 1996 Oct 9;276(14):1147–1151. [PubMed] [Google Scholar]
  13. Edwards Albert O., Ritter Robert, 3rd, Abel Kenneth J., Manning Alisa, Panhuysen Carolien, Farrer Lindsay A. Complement factor H polymorphism and age-related macular degeneration. Science. 2005 Mar 10;308(5720):421–424. doi: 10.1126/science.1110189. [DOI] [PubMed] [Google Scholar]
  14. Edwards Albert O., Ritter Robert, 3rd, Abel Kenneth J., Manning Alisa, Panhuysen Carolien, Farrer Lindsay A. Complement factor H polymorphism and age-related macular degeneration. Science. 2005 Mar 10;308(5720):421–424. doi: 10.1126/science.1110189. [DOI] [PubMed] [Google Scholar]
  15. Freeman Ellen E., Munoz Beatriz, West Sheila K., Tielsch James M., Schein Oliver D. Is there an association between cataract surgery and age-related macular degeneration? Data from three population-based studies. Am J Ophthalmol. 2003 Jun;135(6):849–856. doi: 10.1016/s0002-9394(02)02253-5. [DOI] [PubMed] [Google Scholar]
  16. Friedman David S., O'Colmain Benita J., Muñoz Beatriz, Tomany Sandra C., McCarty Cathy, de Jong Paulus T. V. M., Nemesure Barbara, Mitchell Paul, Kempen John, Eye Diseases Prevalence Research Group Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004 Apr;122(4):564–572. doi: 10.1001/archopht.122.4.564. [DOI] [PubMed] [Google Scholar]
  17. Grossniklaus Hans E., Green W. Richard. Choroidal neovascularization. Am J Ophthalmol. 2004 Mar;137(3):496–503. doi: 10.1016/j.ajo.2003.09.042. [DOI] [PubMed] [Google Scholar]
  18. Hageman G. S., Luthert P. J., Victor Chong N. H., Johnson L. V., Anderson D. H., Mullins R. F. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001 Nov;20(6):705–732. doi: 10.1016/s1350-9462(01)00010-6. [DOI] [PubMed] [Google Scholar]
  19. Hageman Gregory S., Anderson Don H., Johnson Lincoln V., Hancox Lisa S., Taiber Andrew J., Hardisty Lisa I., Hageman Jill L., Stockman Heather A., Borchardt James D., Gehrs Karen M. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A. 2005 May 3;102(20):7227–7232. doi: 10.1073/pnas.0501536102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Haines Jonathan L., Hauser Michael A., Schmidt Silke, Scott William K., Olson Lana M., Gallins Paul, Spencer Kylee L., Kwan Shu Ying, Noureddine Maher, Gilbert John R. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005 Mar 10;308(5720):419–421. doi: 10.1126/science.1110359. [DOI] [PubMed] [Google Scholar]
  21. Hall N. F., Gale C. R., Syddall H., Phillips D. I., Martyn C. N. Risk of macular degeneration in users of statins: cross sectional study. BMJ. 2001 Aug 18;323(7309):375–376. doi: 10.1136/bmj.323.7309.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hammond Christopher J., Webster Andrew R., Snieder Harold, Bird Alan C., Gilbert Clare E., Spector Tim D. Genetic influence on early age-related maculopathy: a twin study. Ophthalmology. 2002 Apr;109(4):730–736. doi: 10.1016/s0161-6420(01)01049-1. [DOI] [PubMed] [Google Scholar]
  23. Hayashi M., Merriam J. E., Klaver C. C. W., Zernant J., Bergen A. A., Smith R. T., Chang S., Merriam J. C., Allikmets R. Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. Ophthalmic Genet. 2004 Jun;25(2):111–119. doi: 10.1080/13816810490514342. [DOI] [PubMed] [Google Scholar]
  24. Klaver C. C., Wolfs R. C., Assink J. J., van Duijn C. M., Hofman A., de Jong P. T. Genetic risk of age-related maculopathy. Population-based familial aggregation study. Arch Ophthalmol. 1998 Dec;116(12):1646–1651. doi: 10.1001/archopht.116.12.1646. [DOI] [PubMed] [Google Scholar]
  25. Klein M. L., Schultz D. W., Edwards A., Matise T. C., Rust K., Berselli C. B., Trzupek K., Weleber R. G., Ott J., Wirtz M. K. Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol. 1998 Aug;116(8):1082–1088. doi: 10.1001/archopht.116.8.1082. [DOI] [PubMed] [Google Scholar]
  26. Klein R., Davis M. D., Magli Y. L., Segal P., Klein B. E., Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991 Jul;98(7):1128–1134. doi: 10.1016/s0161-6420(91)32186-9. [DOI] [PubMed] [Google Scholar]
  27. Klein R., Klein B. E., Jensen S. C., Meuer S. M. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997 Jan;104(1):7–21. doi: 10.1016/s0161-6420(97)30368-6. [DOI] [PubMed] [Google Scholar]
  28. Klein R., Klein B. E., Linton K. L. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992 Jun;99(6):933–943. doi: 10.1016/s0161-6420(92)31871-8. [DOI] [PubMed] [Google Scholar]
  29. Klein Ronald, Klein Barbara E. K., Tomany Sandra C., Cruickshanks Karen J. The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 2003 Jun;110(6):1273–1280. doi: 10.1016/S0161-6420(03)00599-2. [DOI] [PubMed] [Google Scholar]
  30. Klein Ronald, Klein Barbara E. K., Tomany Sandra C., Meuer Stacy M., Huang Guan-Hua. Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye study. Ophthalmology. 2002 Oct;109(10):1767–1779. doi: 10.1016/s0161-6420(02)01146-6. [DOI] [PubMed] [Google Scholar]
  31. Klein Ronald, Klein Barbara E. K., Tomany Sandra C., Moss Scot E. Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. Am J Epidemiol. 2002 Oct 1;156(7):589–598. doi: 10.1093/aje/kwf092. [DOI] [PubMed] [Google Scholar]
  32. Klein Ronald, Klein Barbara E. K., Tomany Sandra C., Moss Scot E. Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. Am J Epidemiol. 2002 Oct 1;156(7):589–598. doi: 10.1093/aje/kwf092. [DOI] [PubMed] [Google Scholar]
  33. Kleinmann Guy, Hoffman Peter, Schechtman Edna, Pollack Ayala. Microscope-induced retinal phototoxicity in cataract surgery of short duration. Ophthalmology. 2002 Feb;109(2):334–338. doi: 10.1016/s0161-6420(01)00924-1. [DOI] [PubMed] [Google Scholar]
  34. Mares-Perlman J. A., Brady W. E., Klein R., VandenLangenberg G. M., Klein B. E., Palta M. Dietary fat and age-related maculopathy. Arch Ophthalmol. 1995 Jun;113(6):743–748. doi: 10.1001/archopht.1995.01100060069034. [DOI] [PubMed] [Google Scholar]
  35. McKay Gareth J., Clarke Stephen, Hughes Anne, McConnell Vivienne, Schultz Dennis W., Klein Michael L., Silvestri Giuliana, Simpson David A. C. A novel diagnostic test detects a low frequency of the hemicentin Gln5345Arg variant among Northern Irish age related macular degeneration patients. Mol Vis. 2004 Sep 24;10:682–687. [PubMed] [Google Scholar]
  36. Meyers S. M., Zachary A. A. Monozygotic twins with age-related macular degeneration. Arch Ophthalmol. 1988 May;106(5):651–653. doi: 10.1001/archopht.1988.01060130705029. [DOI] [PubMed] [Google Scholar]
  37. Michaelides M., Hunt D. M., Moore A. T. The genetics of inherited macular dystrophies. J Med Genet. 2003 Sep;40(9):641–650. doi: 10.1136/jmg.40.9.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Mitchell Paul, Wang Jie Jin, Smith Wayne, Leeder Stephen R. Smoking and the 5-year incidence of age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol. 2002 Oct;120(10):1357–1363. doi: 10.1001/archopht.120.10.1357. [DOI] [PubMed] [Google Scholar]
  39. Mullins R. F., Aptsiauri N., Hageman G. S. Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye (Lond) 2001 Jun;15(Pt 3):390–395. doi: 10.1038/eye.2001.142. [DOI] [PubMed] [Google Scholar]
  40. Mullins R. F., Russell S. R., Anderson D. H., Hageman G. S. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000 May;14(7):835–846. [PubMed] [Google Scholar]
  41. Owen C. G., Fletcher A. E., Donoghue M., Rudnicka A. R. How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom? Br J Ophthalmol. 2003 Mar;87(3):312–317. doi: 10.1136/bjo.87.3.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Penfold P. L., Provis J. M., Billson F. A. Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis. Graefes Arch Clin Exp Ophthalmol. 1987;225(1):70–76. doi: 10.1007/BF02155808. [DOI] [PubMed] [Google Scholar]
  43. Ryan S. J., Mittl R. N., Maumenee A. E. The disciform response: an historical perspective. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;215(1):1–20. doi: 10.1007/BF00413392. [DOI] [PubMed] [Google Scholar]
  44. Schmidt Silke, Klaver Caroline, Saunders Ann, Postel Eric, De La Paz Monica, Agarwal Anita, Small Kent, Udar Nitin, Ong John, Chalukya Meenal. A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Ophthalmic Genet. 2002 Dec;23(4):209–223. doi: 10.1076/opge.23.4.209.13883. [DOI] [PubMed] [Google Scholar]
  45. Schultz Dennis W., Klein Michael L., Humpert Andrea J., Luzier Christina W., Persun Vesna, Schain Mitchell, Mahan Alison, Runckel Charles, Cassera Maria, Vittal Vasavi. Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Hum Mol Genet. 2003 Oct 21;12(24):3315–3323. doi: 10.1093/hmg/ddg348. [DOI] [PubMed] [Google Scholar]
  46. Seddon J. M., Willett W. C., Speizer F. E., Hankinson S. E. A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA. 1996 Oct 9;276(14):1141–1146. [PubMed] [Google Scholar]
  47. Smith W., Assink J., Klein R., Mitchell P., Klaver C. C., Klein B. E., Hofman A., Jensen S., Wang J. J., de Jong P. T. Risk factors for age-related macular degeneration: Pooled findings from three continents. Ophthalmology. 2001 Apr;108(4):697–704. doi: 10.1016/s0161-6420(00)00580-7. [DOI] [PubMed] [Google Scholar]
  48. Snow K. K., Seddon J. M. Do age-related macular degeneration and cardiovascular disease share common antecedents? Ophthalmic Epidemiol. 1999 Jun;6(2):125–143. doi: 10.1076/opep.6.2.125.1558. [DOI] [PubMed] [Google Scholar]
  49. Soubrane G., Bressler N. M. Treatment of subfoveal choroidal neovascularisation in age related macular degeneration: focus on clinical application of verteporfin photodynamic therapy. Br J Ophthalmol. 2001 Apr;85(4):483–495. doi: 10.1136/bjo.85.4.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Stone Edwin M., Braun Terry A., Russell Stephen R., Kuehn Markus H., Lotery Andrew J., Moore Paula A., Eastman Christopher G., Casavant Thomas L., Sheffield Val C. Missense variations in the fibulin 5 gene and age-related macular degeneration. N Engl J Med. 2004 Jul 22;351(4):346–353. doi: 10.1056/NEJMoa040833. [DOI] [PubMed] [Google Scholar]
  51. Sunness J. S., Applegate C. A., Haselwood D., Rubin G. S. Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. Ophthalmology. 1996 Sep;103(9):1458–1466. doi: 10.1016/s0161-6420(96)30483-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Sunness J. S., Rubin G. S., Applegate C. A., Bressler N. M., Marsh M. J., Hawkins B. S., Haselwood D. Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology. 1997 Oct;104(10):1677–1691. doi: 10.1016/s0161-6420(97)30079-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Weeks Daniel E., Conley Yvette P., Tsai Hui-Ju, Mah Tammy S., Schmidt Silke, Postel Eric A., Agarwal Anita, Haines Jonathan L., Pericak-Vance Margaret A., Rosenfeld Philip J. Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet. 2004 May 27;75(2):174–189. doi: 10.1086/422476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Zarbin Marco A. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004 Apr;122(4):598–614. doi: 10.1001/archopht.122.4.598. [DOI] [PubMed] [Google Scholar]
  55. van Leeuwen Redmer, Klaver Caroline C. W., Vingerling Johannes R., Hofman Albert, de Jong Paulus T. V. M. The risk and natural course of age-related maculopathy: follow-up at 6 1/2 years in the Rotterdam study. Arch Ophthalmol. 2003 Apr;121(4):519–526. doi: 10.1001/archopht.121.4.519. [DOI] [PubMed] [Google Scholar]
  56. van Leeuwen Redmer, Tomany Sandra C., Wang Jie Jin, Klein Ronald, Mitchell Paul, Hofman Albert, Klein Barbara E. K., Vingerling Johannes R., Cumming Robert G., de Jong Paulus T. V. M. Is medication use associated with the incidence of early age-related maculopathy? Pooled findings from 3 continents. Ophthalmology. 2004 Jun;111(6):1169–1175. doi: 10.1016/j.ophtha.2003.10.024. [DOI] [PubMed] [Google Scholar]
  57. van der Schaft T. L., Mooy C. M., de Bruijn W. C., Mulder P. G., Pameyer J. H., de Jong P. T. Increased prevalence of disciform macular degeneration after cataract extraction with implantation of an intraocular lens. Br J Ophthalmol. 1994 Jun;78(6):441–445. doi: 10.1136/bjo.78.6.441. [DOI] [PMC free article] [PubMed] [Google Scholar]

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