Abstract
Such tuberculin preparations as are currently used for skin testing in human beings are not specific for tuberculous infection. There is, in particular, reason to believe that the kind of low-grade tuberculin sensitivity that is highly prevalent in many tropical areas is ”non-specific”. A new kind of tuberculin, obtained as supernatant after acid precipitation followed by alcohol precipitation of the unheated concentrate from ultrafiltration of a culture of tubercle bacilli of human type, has been compared with ordinary tuberculin by skin tests in man in East Africa (Malawi) and South India. The results, reported in this paper, indicate that the new preparation gives rise to much smaller non-specific reactions than does the ordinary tuberculin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COMSTOCK G. W., EDWARDS L. B., PHILIP R. N., WINN W. A. A COMPARISON IN THE UNITED STATES OF AMERICA OF TWO TUBERCULINS, PPD-S AND RT 23. Bull World Health Organ. 1964;31:161–170. [PMC free article] [PubMed] [Google Scholar]
- GULD J., BENTZON M. W., BLEIKER M. A., GRIEP W. A., MAGNUSSON M., WAALER H. Standardization of a new batch of purified tuberculin (PPD) intended for international use. Bull World Health Organ. 1958;19(5):845–951. [PMC free article] [PubMed] [Google Scholar]
- Guld J., Roelsgaard E. The effect of Tween 80 on intradermal tuberculin reactions. Bull World Health Organ. 1965;33(3):345–363. [PMC free article] [PubMed] [Google Scholar]
- MAGNUSSON M., BENTZON M. W. Preparation of purified tuberculin RT 23. Bull World Health Organ. 1958;19(5):829–843. [PMC free article] [PubMed] [Google Scholar]
- MAGNUSSON M., GULD J., MAGNUS K., WAALER H. Diluents for stabilization of tuberculin. Bull World Health Organ. 1958;19(5):799–828. [PMC free article] [PubMed] [Google Scholar]
- NISSEN MEYER S. A method for standardization of tuberculin preparations by intracutaneous reactions in humans; comparison of two purified tuberculins. Am Rev Tuberc. 1952 Sep;66(3):292–313. [PubMed] [Google Scholar]