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. 1966;35(1):3–15.

Mosquito-borne haemorrhagic fevers of South and South-East Asia*

Scott B Halstead
PMCID: PMC2476178  PMID: 5297536

Abstract

During the past decade outbreaks of a severe haemorrhagic disease caused by dengue viruses of multiple types have been reported in the Philippines, Thailand, Malaysia, Viet-Nam and eastern India. In many of these outbreaks chikungunya virus, a group A arbovirus, was simultaneously the cause of similar but probably milder disease. Both these viruses appear to be able to be able to produce classical dengue fever in some individuals and disease with haemorrhagic manifestations in others. Because of the growing public health importance and the progressive spread of this disease a unified review of its clinical and epidemiological features has been needed. This paper presents the history and salient clinical features of mosquito-borne haemorrhagic fever and summarizes recent epidemiological studies and current diagnostic and control methods.

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Selected References

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  1. AIKAT B. K., KONAR N. R., BANERJEE G. HAEMORRHAGIC FEVER IN CALCUTTA AREA. Indian J Med Res. 1964 Jul;52:660–675. [PubMed] [Google Scholar]
  2. CAREY D. E., MYERS R. M., REUBEN R. DENGUE TYPES 1 AND 4 VIRUSES IN WILD-CAUGHT MOSQUITOES IN SOUTH INDIA. Science. 1964 Jan 10;143(3602):131–132. doi: 10.1126/science.143.3602.131. [DOI] [PubMed] [Google Scholar]
  3. CHASTEL C. INFECTIONS HUMAINES AU CAMBODGE PAR LE VIRUS CHIKUNGUNYA OU UN AGENT 'ETROITEMENT APPARENT'E. I. CLINIQUE. ISOLEMENTS ET IDENTIFICATION DES VIRUS. S'EROLOGIE. Bull Soc Pathol Exot Filiales. 1963 Sep-Oct;56:892–915. [PubMed] [Google Scholar]
  4. CHEW A., LENG G. A., YUEN H., TEIK K. O., KIAT L. Y., HONG L. C., WELLS R. A haemorrhagic fever in Singapore. Lancet. 1961 Feb 11;1(7172):307–310. doi: 10.1016/s0140-6736(61)91478-7. [DOI] [PubMed] [Google Scholar]
  5. Cohen S. N., Halstead S. B. Shock associated with dengue infection. I. Clinical and physiologic manifestations of dengue hemorrhagic fever in Thailand, 1964. J Pediatr. 1966 Mar;68(3):448–456. doi: 10.1016/s0022-3476(66)80249-4. [DOI] [PubMed] [Google Scholar]
  6. DASANEYAVAJA A., ROBIN Y., YENBUTRA D. Laboratory observations related to prognosis in Thai haemorrhagic fever. J Trop Med Hyg. 1963 Feb;66:35–41. [PubMed] [Google Scholar]
  7. DE S. N., CHOWDHURY B., SEN S. N., MUKHERJEE S., VENKATACHALAM M. A. HEPATIC NECROSIS WITH HAEMORRHAGIC FEVER. J Indian Med Assoc. 1964 Jun 16;42:557–560. [PubMed] [Google Scholar]
  8. GAJDUSEK D. C. Virus hemorrhagic fevers. Special reference to hemorrhagic fever with renal syndrome (epidemic hemorrhagic fever). J Pediatr. 1962 Jun;60:841–857. doi: 10.1016/s0022-3476(62)80170-x. [DOI] [PubMed] [Google Scholar]
  9. HALSTEAD S. B., BUESCHER E. L. Hemorrhagic disease in rodents infected with virus associated with Thai hemorrhagic fever. Science. 1961 Aug 18;134(3477):475–476. doi: 10.1126/science.134.3477.475. [DOI] [PubMed] [Google Scholar]
  10. HALSTEAD S. B., SUKHAVACHANA P., NISALAK A. ASSAY OF MOUSE ADAPTED DENGUE VIRUSES IN MAMMALIAN CELL CULTURES BY AN INTERFERENCE METHOD. Proc Soc Exp Biol Med. 1964 Apr;115:1062–1068. doi: 10.3181/00379727-115-29117. [DOI] [PubMed] [Google Scholar]
  11. HALSTEAD S. B., SUKHAVACHANA P., NISALAK A. IN VITRO RECOVERY OF DENGUE VIRUSES FROM NATURALLY INFECTED HUMAN BEINGS AND ARTHROPODS. Nature. 1964 May 30;202:931–932. doi: 10.1038/202931a0. [DOI] [PubMed] [Google Scholar]
  12. HALSTEAD S. B., YAMARAT C. RECENT EPIDEMICS OF HEMORRHAGIC FEVER IN THAILAND. OBSERVATIONS RELATED TO PATHOGENESIS OF A "NEW" DENGUE DISEASE. Am J Public Health Nations Health. 1965 Sep;55:1386–1395. doi: 10.2105/ajph.55.9.1386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HAMMON W. M., RUDNICK A., SATHER G. E. Viruses associated with epidemic hemorrhagic fevers of the Philippines and Thailand. Science. 1960 Apr 15;131(3407):1102–1103. doi: 10.1126/science.131.3407.1102. [DOI] [PubMed] [Google Scholar]
  14. HAMMON W. M., RUDNICK A., SATHER G., ROGERS K. D., MORSE L. J. New hemorrhagic fevers of children in the Philippines and Thailand. Trans Assoc Am Physicians. 1960;73:140–155. [PubMed] [Google Scholar]
  15. HAMMON W. M., SATHER G. E. VIROLOGICAL FINDINGS IN THE 1960 HEMORRHAGIC FEVER EPIDEMIC (DENGUE) IN THAILAND. Am J Trop Med Hyg. 1964 Jul;13:629–641. doi: 10.4269/ajtmh.1964.13.629. [DOI] [PubMed] [Google Scholar]
  16. Halstead S. B., Voulgaropoulos E. M., Tien N. H., Udomsakdi S. Dengue hemorrhagic fever in South Vietnam: report of the 1963 outbreak. Am J Trop Med Hyg. 1965 Sep;14(5):819–830. doi: 10.4269/ajtmh.1965.14.819. [DOI] [PubMed] [Google Scholar]
  17. Jadhav M., Namboodripad M., Carman R. H., Carey D. E., Myers R. M. Chikungunya disease in infants and children in Vellore: a report of clinical and haematological features of virologically proved cases. Indian J Med Res. 1965 Aug;53(8):764–776. [PubMed] [Google Scholar]
  18. LIM K. A., CHAN Y. C., PHOON W. O., HANAM E. DENGUE-TYPE VIRUSES ISOLATED IN SINGAPORE. Bull World Health Organ. 1964;30:227–240. [PMC free article] [PubMed] [Google Scholar]
  19. LIM K. A., RUDNICK A., CHAN Y. C. Recent studies of haemorrhatic fevers in Singapore. Singapore Med J. 1961 Dec;2:158–161. [PubMed] [Google Scholar]
  20. NELSON E. R., BIERMAN H. R., CHULAJATA R. HEMATOLOGIC FINDINGS IN THE 1960 HEMORRHAGIC FEVER EPIDEMIC (DENGUE) IN THAILAND. Am J Trop Med Hyg. 1964 Jul;13:642–649. doi: 10.4269/ajtmh.1964.13.642. [DOI] [PubMed] [Google Scholar]
  21. NELSON E. R. Hemorrhagic fever in children in Thailand. Report of 69 cases. J Pediatr. 1960 Jan;56:101–108. doi: 10.1016/s0022-3476(60)80294-6. [DOI] [PubMed] [Google Scholar]
  22. PAVRI K. M., BANERJEE G., ANDERSON C. R., AIKAT B. K. VIROLOGICAL AND SEROLOGICAL STUDIES OF CASES OF HAEMORRHAGIC FEVER IN CALCUTTA: MATERIAL COLLECTED BY THE INSTITUTE OF POST-GRADUATE MEDICAL EDUCATION AND RESEARCH, CALCUTTA. Indian J Med Res. 1964 Jul;52:692–697. [PubMed] [Google Scholar]
  23. PIYARATN P. Pathology of Thailand epidemic hemorrhagic fever. Am J Trop Med Hyg. 1961 Sep;10:767–772. doi: 10.4269/ajtmh.1961.10.767. [DOI] [PubMed] [Google Scholar]
  24. RAMAKRISHNAN S. P., GELFAND H. M., BOSE P. N., SEHGAL P. N., MUKHERJEE R. N. THE EPIDEMIC OF ACUTE HAEMORRHAGIC FEVER, CALCUTTA, 1963: EPIDEMIOLOGICAL INQUIRY. Indian J Med Res. 1964 Jul;52:633–650. [PubMed] [Google Scholar]
  25. ROBIN Y., YENBUTRA D., DASANEYAVAJA A. UNE M'ETHODE D'ISOLEMENT DE VIRUS 'A PARTIR DE MOUSTIQUES VECTEURS. ISOLEMENT DE LA PREMIERE SOUCHE DE VIRUS DE L'ENCEPHALITE JAPONAISE B EN THAILANDE. Med Trop (Mars) 1963 Nov-Dec;23:781–787. [PubMed] [Google Scholar]
  26. Rao T. R., Carey D. E., Pavri K. M. Preliminary isolation and identification of chikungunya virus from cases of dengue-like illness in Madras city. Indian J Med Res. 1965 Aug;53(8):689–693. [PubMed] [Google Scholar]
  27. SARKAR J. K., CHATTERJEE S. N., CHAKRAVARTY S. K. HAEMORRHAGIC FEVER IN CALCUTTA: SOME EPIDEMIOLOGICAL OBSERVATIONS. Indian J Med Res. 1964 Jul;52:651–659. [PubMed] [Google Scholar]
  28. SARKAR J. K., PAVRI K. M., CHATTERJEE S. N., CHAKRAVARTY S. K., ANDERSON C. R. VIROLOGICAL AND SEROLOGICAL STUDIES OF CASES OF HAEMORRHAGIC FEVER IN CALCUTTA. MATERIAL COLLECTED BY THE CALCUTTA SCHOOL OF TROPICAL MEDICINE. Indian J Med Res. 1964 Jul;52:684–691. [PubMed] [Google Scholar]
  29. SHAH K. V., GIBBS C. J., Jr, BANERJEE G. VIROLOGICAL INVESTIGATION OF THE EPIDEMIC OF HAEMORRHAGIC FEVER IN CALCUTTA: ISOLATION OF THREE STRAINS OF CHIKUNGUNYA VIRUS. Indian J Med Res. 1964 Jul;52:676–683. [PubMed] [Google Scholar]
  30. SHAH K. V., GILOTRA S. K., GIBBS C. J., Jr, ROZEBOOM L. E. LABORATORY STUDIES OF TRANSMISSION OF CHIKUNGUNYA VIRUS BY MOSQUITOES: A PRELIMINARY REPORT. Indian J Med Res. 1964 Jul;52:703–709. [PubMed] [Google Scholar]
  31. Sarkar J. K., Chatterjee S. N., Chakravarti S. K., Mitra A. C. Chikungunya virus infection with haemorrhagic manifestations. Indian J Med Res. 1965 Oct;53(10):921–925. [PubMed] [Google Scholar]

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