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. 1967;36(6):901–911.

Splenomegaly in New Guinea*

P D Marsden, D H Connor, A Voller, A Kelly, F D Schofield, M S R Hutt
PMCID: PMC2476368  PMID: 5299859

Abstract

Seeking to determine whether there is a relationship in New Guineans between hepatic sinusoidal infiltration and splenomegaly on the one hand and malaria on the other, the authors studied 24 adults from a village protected from malaria for 5 years by 6-monthly DDT spraying and 34 adults from an unprotected village with hyperendemic malaria.

It was found that clinical splenomegaly tended to be associated with greater hepatic sinusoidal infiltration among persons from the malarious village and that higher malaria antibody titres were more common in patients with splenomegaly in this village. In adults in the protected village the prevalence of malaria parasitaemia was much lower than in the malarious village and the sinusoidal infiltrates were also diminished.

No associations between parasitaemia, malaria antibody titre, and hepatic sinusoidal infiltration could be demonstrated in the malarious village. The implications of these findings are discussed and the question of malaria being responsible for the marked splenomegaly encountered in tropical practice is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRUCE-CHWATT L. J. A LONGITUDINAL LONGITUDINAL SURVEY OF NATURAL MALARIA INFECTION IN A GROUP OF WEST AFRICAN ADULTS. I. West Afr Med J. 1963 Aug;12:141–173. [PubMed] [Google Scholar]
  2. BRUCE-CHWATT L. J. Biometric study of spleen- and liver-weights in Africans and Europeans, with special reference to endemic malaria. Bull World Health Organ. 1956;15(3-5):513–548. [PMC free article] [PubMed] [Google Scholar]
  3. CATTOIR E., MARILL F. G. Vue d'ensemble sur les splénomégalies chroniques dites "algériennes". Cah Med Union Fr. 1950 Jul-Sep;5(42):585–591. [PubMed] [Google Scholar]
  4. CHAUDHURI R. N., SAHA T. K., BASU S. P., MUKHERJEE A. M., CHAUDHURI M. N. R. Chronic splenomegaly. Indian J Med Res. 1956 Apr;44(2):305–323. [PubMed] [Google Scholar]
  5. COVELL G. Relationship between malarial parasitaemia and symptoms of the disease: a review of the literature. Bull World Health Organ. 1960;22:605–619. [PMC free article] [PubMed] [Google Scholar]
  6. Dowling M. A., Shute G. T. A comparative study of thick and thin blood films in the diagnosis of scanty malaria parasitaemia. Bull World Health Organ. 1966;34(2):249–267. [PMC free article] [PubMed] [Google Scholar]
  7. FAWDRY A. L. Syndrome of splenomegaly, anaemia, and hepatomegaly often left-lobed, in South Arabia. Trans R Soc Trop Med Hyg. 1955 Jul;49(4):387–398. doi: 10.1016/0035-9203(55)90062-6. [DOI] [PubMed] [Google Scholar]
  8. GEBBIE D. A., HAMILTON P. J., HUTT M. S., MARSDEN P. D., VOLLER A., WILKS N. E. MALARIAL ANTIBODIES IN IDIOPATHIC SPLENOMEGALY IN UGANDA. Lancet. 1964 Aug 22;2(7356):392–393. doi: 10.1016/s0140-6736(64)90396-4. [DOI] [PubMed] [Google Scholar]
  9. KONAR N. R., CHOUDHURY D. C. R. Response of tropical splenomegaly of unknown aetiology to induced benign tertian malaria. Indian J Med Res. 1955 Oct;43(4):685–688. [PubMed] [Google Scholar]
  10. LEATHER H. M. Portal hypertension and gross splenomegaly in Uganda. Br Med J. 1961 Jan 7;1(5218):15–18. doi: 10.1136/bmj.1.5218.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Leonard P. J., Shaper A. G. Serum proteins in African and Asian subjects in Kampala, Uganda. East Afr Med J. 1965 Dec;42(12):689–691. [PubMed] [Google Scholar]
  12. MARSDEN P. D., HUTT M. S., WILKS N. E., VOLLER A., BLACKMAN V., SHAH K. K., CONNOR D. H., HAMILTON P. J., BANWELL J. G., LUNN H. F. AN INVESTIGATION OF TROPICAL SPLENOMEGALY AT MULAGO HOSPITAL, KAMPALA, UGANDA. Br Med J. 1965 Jan 9;1(5427):89–92. doi: 10.1136/bmj.1.5427.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MUSTAFA D. GROSS SPLENOMEGALY IN THE SUDAN. J Trop Med Hyg. 1965 Aug;68:183–188. [PubMed] [Google Scholar]
  14. PETERS W., STANDFAST H. A. Studies on the epidemiology of malaria in New Guinea. Part II. Holoendemic malaria--the entomological picture. Trans R Soc Trop Med Hyg. 1960 May;54:249–254. doi: 10.1016/0035-9203(60)90069-9. [DOI] [PubMed] [Google Scholar]
  15. PETERS W., STANDFAST H. Report on a malaria survey in the Sepik district. Med J Aust. 1957 Jun 22;44(25):861–868. doi: 10.5694/j.1326-5377.1957.tb59970.x. [DOI] [PubMed] [Google Scholar]
  16. PETERS W. Studies on the epidemiology of malaria in New Guinea. Part I. Holoendemic malaria--the clinical picture. Trans R Soc Trop Med Hyg. 1960 May;54:242–249. doi: 10.1016/0035-9203(60)90068-7. [DOI] [PubMed] [Google Scholar]
  18. SAHA T. K., CHAUDHURI R. N. Hepatic pathology in tropical splenomegaly. Indian J Med Sci. 1957 Sep;11(9):704–707. [PubMed] [Google Scholar]
  19. SCHOFIELD F. D. Differences in palpable liver and spleen rates between men and women of the Sepik District, New Guinea The effects of pregnancy and lactation. Trans R Soc Trop Med Hyg. 1962 Jan;56:60–69. doi: 10.1016/0035-9203(62)90089-5. [DOI] [PubMed] [Google Scholar]
  20. SCHOFIELD F. D., PARKINSON A. D., KELLY A. CHANGES IN HAEMOGLOBIN VALUES AND HEPATOSPLENOMEGALY PRODUCED BY CONTROL OF HOLOENDEMIC MALARIA. Br Med J. 1964 Mar 7;1(5383):587–591. doi: 10.1136/bmj.1.5383.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. SCHOFIELD F. D., PARKINSON A. D. Social medicine in New Guinea: beliefs and practices affecting health among the Abelam and Wam peoples of the Sepik district. II. Med J Aust. 1963 Jan 12;50(1):29–33. [PubMed] [Google Scholar]
  22. TELCHAROV L., TODOROWA M. Le foie des paludéens; étudié sur 45 cas au moyen de ponctions-biopsies. Sem Hop. 1950 Jun 10;26(43):2072–2075. [PubMed] [Google Scholar]
  23. VOLLER A. FLUORESCENT ANTIBODY METHODS AND THEIR USE IN MALARIA RESEARCH. Bull World Health Organ. 1964;30:343–354. [PMC free article] [PubMed] [Google Scholar]
  24. WALTERS J. H., McGREGOR I. A. The mechanism of malarial hepatomegaly and its relationship to hepatic fibrosis. Trans R Soc Trop Med Hyg. 1960 Mar;54:135–145. doi: 10.1016/0035-9203(60)90050-x. [DOI] [PubMed] [Google Scholar]
  25. Williams R. Portal hypertension in idiopathic tropical splenomegaly. Lancet. 1966 Feb 12;1(7433):329–333. doi: 10.1016/s0140-6736(66)91319-5. [DOI] [PubMed] [Google Scholar]

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