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. 1989 Mar;63(3):1049–1053. doi: 10.1128/jvi.63.3.1049-1053.1989

Maternal transmission of retroviral disease and strategies for preventing infection of the neonate.

A H Sharpe 1, J J Hunter 1, R M Ruprecht 1, R Jaenisch 1
PMCID: PMC247797  PMID: 2915376

Abstract

Moloney murine leukemia virus is efficiently transmitted from viremic mothers to offspring, primarily via virus-containing milk. To determine the level in the infectious process at which an antiviral agent can interfere most effectively with perinatal viral transmission, we examined the effect of the drug 3'-azido-3'-deoxythymidine (AZT) on transmission of Moloney murine leukemia virus from viremic mothers to offspring. Although AZT treatment did not affect the titer of virus in milk, it did suppress the development of viremia in all offspring. AZT, however, did not prevent transmission of virus from viremic mothers to 25% of the offspring, but did lead to a marked reduction in virus load in these infected mice. These results provide evidence for effective antiretroviral therapy during gestation and in the perinatal period and are of potential significance for the management of maternal transmission of human retroviruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ando Y., Nakano S., Saito K., Shimamoto I., Ichijo M., Toyama T., Hinuma Y. Transmission of adult T-cell leukemia retrovirus (HTLV-I) from mother to child: comparison of bottle- with breast-fed babies. Jpn J Cancer Res. 1987 Apr;78(4):322–324. [PubMed] [Google Scholar]
  2. Buffett R. F., Grace J. T., Jr, DiBerardino L. A., Mirand E. A. Vertical transmission of murine leukemia virus. Cancer Res. 1969 Mar;29(3):588–595. [PubMed] [Google Scholar]
  3. Friedland G. H., Klein R. S. Transmission of the human immunodeficiency virus. N Engl J Med. 1987 Oct 29;317(18):1125–1135. doi: 10.1056/NEJM198710293171806. [DOI] [PubMed] [Google Scholar]
  4. Hartshorn K. L., Vogt M. W., Chou T. C., Blumberg R. S., Byington R., Schooley R. T., Hirsch M. S. Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon. Antimicrob Agents Chemother. 1987 Feb;31(2):168–172. doi: 10.1128/aac.31.2.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ho D. D., Hartshorn K. L., Rota T. R., Andrews C. A., Kaplan J. C., Schooley R. T., Hirsch M. S. Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro. Lancet. 1985 Mar 16;1(8429):602–604. doi: 10.1016/s0140-6736(85)92144-0. [DOI] [PubMed] [Google Scholar]
  6. Ida N., Fukuhara A., Ohba Y. Several aspects of vertical transmission of Moloney virus. Natl Cancer Inst Monogr. 1966 Sep;22:287–311. [PubMed] [Google Scholar]
  7. Jaenisch R. Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos. Cell. 1980 Jan;19(1):181–188. doi: 10.1016/0092-8674(80)90399-2. [DOI] [PubMed] [Google Scholar]
  8. Law L. W. Transmission studies of a leukemogenic virus, MLV, in mice. Natl Cancer Inst Monogr. 1966 Sep;22:267–285. [PubMed] [Google Scholar]
  9. Lifson A. R. Do alternate modes for transmission of human immunodeficiency virus exist? A review. JAMA. 1988 Mar 4;259(9):1353–1356. [PubMed] [Google Scholar]
  10. MCBURNEY J. J., MEIER H., HOAG W. G. DEVICE FOR MILKING MICE. J Lab Clin Med. 1964 Sep;64:485–487. [PubMed] [Google Scholar]
  11. Mitsuya H., Weinhold K. J., Furman P. A., St Clair M. H., Lehrman S. N., Gallo R. C., Bolognesi D., Barry D. W., Broder S. 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A. 1985 Oct;82(20):7096–7100. doi: 10.1073/pnas.82.20.7096. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nakano S., Ando Y., Saito K., Moriyama I., Ichijo M., Toyama T., Sugamura K., Imai J., Hinuma Y. Primary infection of Japanese infants with adult T-cell leukaemia-associated retrovirus (ATLV): evidence for viral transmission from mothers to children. J Infect. 1986 May;12(3):205–212. doi: 10.1016/s0163-4453(86)94086-7. [DOI] [PubMed] [Google Scholar]
  13. Nobis P., Jaenisch R. Passive immunotherapy prevents expression of endogenous Moloney virus and amplification of proviral DNA in BALB/Mo mice. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3677–3681. doi: 10.1073/pnas.77.6.3677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. RUBIN H., CORNELIUS A., FANSHIER L. The pattern of congenital transmission of an avian lekosis virus. Proc Natl Acad Sci U S A. 1961 Jul 15;47:1058–1069. doi: 10.1073/pnas.47.7.1058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rowe W. P., Pugh W. E., Hartley J. W. Plaque assay techniques for murine leukemia viruses. Virology. 1970 Dec;42(4):1136–1139. doi: 10.1016/0042-6822(70)90362-4. [DOI] [PubMed] [Google Scholar]
  16. Ruprecht R. M., O'Brien L. G., Rossoni L. D., Nusinoff-Lehrman S. Suppression of mouse viraemia and retroviral disease by 3'-azido-3'-deoxythymidine. Nature. 1986 Oct 2;323(6087):467–469. doi: 10.1038/323467a0. [DOI] [PubMed] [Google Scholar]
  17. Sen G. C., Herz R., Davatelis V., Pestka S. Antiviral and protein-inducing activities of recombinant human leukocyte interferons and their hybrids. J Virol. 1984 May;50(2):445–450. doi: 10.1128/jvi.50.2.445-450.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sharpe A. H., Jaenisch R., Ruprecht R. M. Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy. Science. 1987 Jun 26;236(4809):1671–1674. doi: 10.1126/science.3037694. [DOI] [PubMed] [Google Scholar]
  19. Thiry L., Sprecher-Goldberger S., Jonckheer T., Levy J., Van de Perre P., Henrivaux P., Cogniaux-LeClerc J., Clumeck N. Isolation of AIDS virus from cell-free breast milk of three healthy virus carriers. Lancet. 1985 Oct 19;2(8460):891–892. doi: 10.1016/s0140-6736(85)90156-4. [DOI] [PubMed] [Google Scholar]

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