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. 1989 Mar;63(3):1465–1469. doi: 10.1128/jvi.63.3.1465-1469.1989

Identification of a transforming gene of human papillomavirus type 16.

A Tanaka 1, T Noda 1, H Yajima 1, M Hatanaka 1, Y Ito 1
PMCID: PMC247853  PMID: 2536847

Abstract

Previously, we observed sequential two-step alteration, growth stimulation, and progression to a more malignant state in NIH 3T3 cells transfected by human papillomavirus type 16 (HPV-16) DNA. In this study, we prepared a cDNA library from RNA extracted from cells transfected with the HPV-16 DNA and isolated cDNA clones which had growth-stimulating activity. Analysis of these cDNA clones indicated that the E7 open reading frame alone is responsible for inducing both steps of this cell transformation.

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Selected References

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