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. 1990 Sep;64(9):4589–4592. doi: 10.1128/jvi.64.9.4589-4592.1990

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.

J S Williamson 1, S A Stohlman 1
PMCID: PMC247935  PMID: 2166833

Abstract

Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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