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. 1990 Oct;64(10):5177–5182. doi: 10.1128/jvi.64.10.5177-5182.1990

Biological and molecular variability of human immunodeficiency virus type 2 isolates from The Gambia.

T F Schulz 1, D Whitby 1, J G Hoad 1, T Corrah 1, H Whittle 1, R A Weiss 1
PMCID: PMC248013  PMID: 1975844

Abstract

Seven new human immunodeficiency virus type 2 (HIV-2) isolates (CBL-20 to CBL-26) from The Gambia were characterized. Their cytopathogenicity and growth in vitro correlated with the severity of clinical disease. CBL-22 was highly sensitive to neutralization by HIV-2 sera and was cross-neutralized by some HIV-1 sera. These findings, the differing sizes of envelope glycoproteins of individual isolates, and the sequence analysis of amplified regions of the viral DNAs show that these HIV-2 isolates from one geographical region in West Africa exhibit biological and genome variability comparable to that observed for HIV-1.

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Selected References

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